Evaluating IL-21 as a Potential Therapeutic Target in Crohn’s Disease

Figure 6

IL-21 expression is upregulated in mesenteric lymph node and lamina propria CD4⁺ T cells from mice with AdTr colitis. Frequency of CD4⁺IL-21⁺-positive T cells in the lamina propria on days 7, 17, 29, and 38 versus BALB/c controls (a). Frequency of CD4⁺IL-21⁺-positive T cells in mesenteric lymph nodes on days 7, 17, 29, and 38 versus BALB/c controls (b). Frequency of CD4⁺IL-21⁺-positive T cells versus delta weight loss in mice with AdTr (c).

(a)

(b)

(c)