Evaluating IL-21 as a Potential Therapeutic Target in Crohn’s Disease

Figure 7

Cytokine and chemokine secretion from mesenteric lymph CD4⁺ T cells stimulated with anti-CD3 and/or IL-21. CD4⁺ T cells were isolated from mesenteric lymph nodes from mice with AdTr colitis. IFN-γ (a), TNF-α (b), GM-CSF (c), CCL3 (d), IL-17 (e), CCL5 (f), IL-4 (g), and CCL4 (h) secretion from in vitro stimulated CD4⁺ T cells. Cells were stimulated with plate bound anti-CD3 and/or IL-21 in combination with anti-IL-21 or isotype control (mouse IgG1).

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)