Evaluating IL-21 as a Potential Therapeutic Target in Crohn’s Disease

Figure 8

Prophylactic treatment of AdTr mice with anti-IL-21 mAb ameliorates colitis. Open circles indicate individual anti-IL-21 mAb-treated mice, black squares indicate individual mIgG1-treated mice, and grey triangles indicate individual control SCID mice. Delta body weight change over time (a). White blood cell count on day 28 (b). Frequency of CD4⁺TCRb⁺ T cell in blood on day 28 (c). Colon weight : length ratio (d). Endoscopic score encompassing (thickening of the colon, changes of vascular pattern, visible fibrin, granularity of mucosal surface, and stool consistency) on day 28 (e). Pictures showing representing images of the colon in anti-IL-21 mAb-treated mice (left), mIgG1-treated mice (middle), and SCID control mice (right) (f).

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