Systematic Review with Network Meta-Analysis: Efficacy of Induction Therapy with a Second Biological Agent in Anti-TNF-Experienced Crohn’s Disease Patients

Figure 3

Network diagrams of published studies for induction of remission (a) and response (b) in anti-TNF-experienced CD patients. In brief, circles correspond to each intervention as a node while lines represent the direct comparisons. The size of each circle indicates the number of included participants for each corresponding treatment, and line thickness indicates the number of studies included in each comparison. Placebo as expected is represented by the biggest node. ADA = adalimumab; USTE = ustekinumab; VEDO = vedolizumab; NAT = natalizumab; CERT = certolizumab; PL = placebo.

(a)

(b)