Efficacy of Mesoglycan in Pain Control after Excisional Hemorrhoidectomy: A Pilot Comparative Prospective Multicenter Study

Table 2

Proportion of patients experiencing pain after defecation, bleeding, absence of thrombosis, time to wound healing, and return to normal activity at each time point (in all patients and in the mesoglycan-treated group) and results of the generalized estimating equations (GEE) models.

	All patients	Meso group	Control group	Fisher’s test
No pain at defecation—T2	69/95 (72.6%)	37/50 (74.0%)	32/45 (71.1%)	0.8198
No pain at defecation—T3	76/93 (81.7%)	38/49 (77.6%)	38/44 (86.4%)	0.2974
No pain at defecation—T4	85/95 (89.5%)	45/51 (88.2%)	40/44 (90.9%)	0.7475
No bleeding—T1	94/97 (96.9%)	51/52 (98.1%)	43/45 (95.6%)	0.5953
No bleeding—T2	78/94 (83.0%)	39/49 (79.6%)	39/45 (86.7%)	0.4192
No bleeding—T3	90/94 (95.7%)	47/50 (94.0%)	43/44 (97.7%)	0.6200
No bleeding—T4	91/93 (97.8%)	50/51 (98.0%)	41/42 (97.6%)	1.0000
Arm (meso versus control)				0.488
No thrombosis—T1	90/97 (92.8%)	48/52 (92.3%)	42/45 (93.3%)	1.0000
No thrombosis—T2	87/93 (93.5%)	47/48 (97.9%)	40/45 (88.9%)	0.1037
No thrombosis—T3	88/94 (93.6%)	47/50 (94.0%)	41/44 (93.2%)	1.000
No thrombosis—T4	91/92 (98.9%)	48/49 (98.0%)	43/43 (100%)	1.000
Arm (meso versus control)				0.332
Wound healing—T2	0/93 (0%)	0/48 (0%)	0/45 (0%)	1.000
Wound healing—T3	1/94 (1.1%)	1/50 (2.0%)	0/44 (0%)	1.000
Wound healing—T4	67/93 (72.0%)	38/51 (74.5%)	29/42 (69.0%)	0.6447
Arm (meso versus control)				0.457
Return to activity—T2	16/91 (17.6%)	10/47 (21.3%)	6/44 (13.6%)	0.4144
Return to activity—T3	58/94 (61.7%)	34/50 (68.0%)	24/44 (54.5%)	0.2067
Return to activity—T4	77/93 (82.8%)	46/49 (93.9%)	31/44 (70.5%)	0.0048
Arm (meso versus control)				0.009