Is Combination Antiviral Therapy Mandatory for Maintenance Therapy in Fully Suppressed Multidrug-Resistant Hepatitis B Patients?

Figure 2

Extended Kaplan-Meier curves of cumulative incidence of virologic breakthrough, stratified by time-varying TDF monotherapy status. The index date was set as the date of complete virologic suppression. Hazard ratio (HR), 95% confidence intervals (CI), and values were calculated by the time-varying Cox proportional hazard model with the time-varying covariate. CI: confidence interval; HR: hazard ratio; no.: number; TDF: tenofovir disoproxil fumarate.