Different Anatomical Subsites of Colon Cancer and Mortality: A Population-Based Study

Table 3

Crude and adjusted hazard ratios for overall survival between right- and left-sided cancers by year, age, stage, and therapy.

Cohort	Crude HR (95% CI)		Adjusted HR (95% CI)
Year at diagnosis
All	0.86 (0.85, 0.87)	<0.001	0.92 (0.92, 0.93)	<0.001
1973–1982	0.88 (0.86, 0.90)	<0.001	0.96 (0.94, 0.98)	<0.001
1983–1992	0.91 (0.89,0.94)	<0.001	0.98 (0.97,1.00)	0.059
1993–2002	0.89 (0.87,0.91)	<0.001	0.95 (0.94,0.97)	<0.001
2003–2012	0.83 (0.81, 0.84)	<0.001	0.91 (0.89,0.92)	<0.001
Age at diagnosis
All	0.86 (0.85, 0.87)	<0.001	0.92 (0.92, 0.93)	<0.001
<50 y	0.89 (0.86, 0.92)	<0.001	0.88 (0.85, 0.91)	<0.001
50–69 y	0.87 (0.86, 0.88)	<0.001	0.89 (0.88, 0.91)	<0.001
70 y	1.00 (0.99, 1.01)	0.423	1.02 (1.00, 1.03)	0.006
SEER stage
All	0.86 (0.85, 0.87)	<0.001	0.92 (0.92, 0.93)	<0.001
Localized	0.81 (0.79, 0.82)	<0.001	0.99 (0.98,1.01)	0.323
Regional	0.90 (0.89,0.91)	<0.001	0.99 (0.98,1.00)	0.156
Distant	0.80 (0.79,0.82)	<0.001	0.81 (0.79,0.82)	<0.001
Surgery
Yes	0.85 (0.85–0.86)	<0.001	0.92 (0.92, 0.93)	<0.001
None	0.81 (0.75–0.88)	<0.001	0.82 (0.79–0.85)	<0.001
Radiation
Yes	0.54 (0.52–0.56)	<0.001	0.69 (0.66–0.72)	<0.001
None	0.86 (0.85–0.86)	<0.001	0.94 (0.93–0.94)	<0.001
Chemotherapy
Yes	0.87 (0.86–0.88)	<0.001	0.83 (0.82–0.84)	<0.001
None/unknown	0.85 (0.84–0.85)	<0.001	0.96 (0.95–0.97)	<0.001

HR: hazard ratio; CI: confidence interval. Adjusted for age, gender, race, year, insurance status, marital status, grade, surgery, radiation, and SEER stage. Right-sided cancer as conference.