Diagnostic Potential of Systemic Eosinophil-Associated Cytokines and Growth Factors in IBD

Table 2

Diagnostic power of eosinophil-associated cytokines as markers differentiating active UC from CD.

(a)

Marker	AUC (95% CI), AUC = 0.5	Cut-off	Sens.&Spec.	index
Eotaxin	0.708 (0.62–0.78),	>138 pg/ml	71 and 68%	0.391
IL13	0.604 (0.52–0.69),	>20.8 pg/ml	51 and 69%	0.203
IFNγ	0.594 (0.51–0.68),	>64.5 pg/ml	76 and 44%	0.199
hsCRP	0.657 (0.57–0.74),	≥19.9 mg/l	74 and 60%	0.347

(b)

Panel	AUC (95% CI)		Difference
	Learning set	Validation set	statistics,
Eotaxin, hsCRP, IFNγ	0.78 (0.7–0.87)	0.73 (0.63–0.82)	0. 818,

hsCRP was tested as an indicator of CD. AUC: area under ROC curve; Sens.&Spec.: sensitivity and specificity; index: Youden index.