Diagnostic Potential of Systemic Eosinophil-Associated Cytokines and Growth Factors in IBD

Table 3

Diagnostic power of eosinophil-associated cytokines as negative markers of mucosal healing in UC.

(a)

Marker	AUC (95% CI), AUC = 0.5	Cut-off	Sens.&Spec.	index
GM-CSF	0.907 (0.80–0.97),	≤16.7 pg/ml	69 and 97%	0.661
IFNγ	0.782 (0.65–0.88),	≤83.2 pg/ml	100 and 60%	0.595
IL12(p70)	0.709 (0.57–0.83),	≤21.6 pg/ml	50 and 100%	0.500
hsCRP	0.673 (0.52–0.80),	≤0.5 mg/l	54 and 83%	0.367

(b)

Panel	AUC (95% CI), AUC = 0.5		Difference
	Learning set	Validation set	statistics,
GM-CSF	0.907 (0.80–0.97)	0.884 (0.78–0.99)	0.335,

AUC: area under ROC curve; Sens.&Spec.: sensitivity and specificity; index: Youden index.