Diagnostic Potential of Systemic Eosinophil-Associated Cytokines and Growth Factors in IBD

Table 4

Diagnostic power of eosinophil-associated cytokines as markers differentiating active IBD from IBS.

(a)

Marker	AUC (95% CI), AUC = 0.5	Cut-off	Sens.&Spec.	index
IL5	0.69 (0.61–0.76),	>9.68 pg/ml	48.6 and 87.5%	0.361
IL8	0.91 (0.85–0.95),	>36.8 pg/ml	82.1 and 87.5%	0.696
IL12(p70)	0.75 (0.67–0.81),	>22.6 pg/ml	99.3 and 50%	0.493
TNFα	0.74 (0.66–0.81),	>34 pg/ml	54.3 and 93.8%	0.480
GM-CSF	0.77 (0.7–0.84),	>24 pg/ml	89.3 and 62.5%	0.518

(b)

Panel	AUC (95% CI), AUC = 0.5		Difference
	Learning set	Validation set	z statistics,
IL8	0.91 (0.85–0.95),	0.87 (0.76–0.98),	0.503,

AUC: area under ROC curve; Sens.&Spec.: sensitivity and specificity; index: Youden index.