Association of Three Polymorphisms rs11614913, rs2910146, and rs3746444 in miRNA-196a2, miRNA-146a, and miRNA-499 with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Table 1

Characteristics of studies included in the meta-analysis.

Study	Year	Country	Ethnicity	Control			Diseases	Case			for HWE	Quality score
miR196a2rs11614913 T>C				CC	TC	TT		CC	TC	TT
Ranjha et al.	2017	India	Caucasian	305	81	55	UC	102	81	14	<0.0001	6
Ciccacci et al.	2017	Italy	Caucasian	101	115	23	IBD	171	172	38	0.234	8
							UC	94	91	21
							CD	77	81	17
Zhu et al.	2016	China	Asian	102	213	135	IBD	117	214	137	0.306	8
							UC	67	108	66
							CD	50	106	71
Gazouli et al.	2013	Greece	Caucasian	108	144	48	IBD	181	199	72	1	7
							UC	98	91	21
							CD	83	108	51
Okubo et al.	2011	Japan	Asian	75	206	122	UC	30	82	58	0.465	8
miRNA146a rs2910164 G>C	GG	CG	CC		GG	CG	CC
Ciccacci et al.	2017	Italy	Caucasian	20	88	144	IBD	39	188	277	0.213	8
							UC	16	71	119
							CD	23	117	158
Zhu et al.	2016	China	Asian	97	202	151	IBD	62	225	181	0.059	7
							UC	32	113	96
							CD	30	112	85
Gazouli et al.	2013	Greece	Caucasian	200	90	10	IBD	231	191	30	0.974	7
							UC	126	78	6
							CD	105	113	24
Okubo et al.	2011	Japan	Asian	74	178	151	UC	28	67	75	0.095	8
miRNA499 rs3746444 A>G	AA	GA	GG		AA	GA	GG
Ranjha et al.	2017	India	Caucasian	167	220	54	UC	97	35	65	0.154	8
Ciccacci et al.	2017	Italy	Caucasian	139	98	15	IBD	209	153	25	0.677	8
							UC	108	87	11
							CD	101	66	14
Zhu et al.	2016	China	Asian	339	105	6	IBD	357	105	6	0.504	8
							UC	185	54	2
							CD	172	51	4
Okubo et al.	2011	Japan	Asian	272	111	20	UC	102	62	6	0.055	7