Association of Three Polymorphisms rs11614913, rs2910146, and rs3746444 in miRNA-196a2, miRNA-146a, and miRNA-499 with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Table 2
Polled ORs of SNPs and IBD.
n
OR (95% CI) P
PH
OR (95% CI) P
PH
OR (95% CI) P
PH
OR (95% CI) P
PH
OR (95% CI) P
PH
miR196a2 C>T
T/C Allelic model
TT/CC Homozygote model
TC/CC Heterozygote model
TT + TC/CC Dominant model
TT/TC + CC Recessive model
Ethnicity
Overall
0.98 (0.85–1.13)
0.019
0.92 (0.76–1.11)
0.18
1.03 (0.74–1.43)
<0.001
1.04 (0.79–1.36)
<0.001
0.97 (0.83–1.14)
0.12
Caucasian
0.99 (0.78–1.25)
0.005
0.88 (0.60–1.27)
0.099
1.10 (0.66–1.83)
<0.001
1.10 (0.72–1.66)
<0.001
0.88 (0.59–1.30)
0.049
Asian
0.97 (0.90–1.07)
0.4
0.96 (0.73–1.25)
0.32
0.91 (0.71–1.16)
0.58
0.92 (0.74–1.16)
0.40
1.03 (0.83–1.14)
0.50
Diseases
UC
5
0.94 (0.76–1.17)
0.007
0.79 (0.62–1.00)
0.23
1.07 (0.62–1.84)
<0.001
1 (0.64–1.53)
<0.001
0.87 (0.71–1.06)
0.11
CD
3
1.06 (0.92–1.22)
0.65
1.16 (0.86–1.56)
0.65
0.97 (0.77–1.22)
0.95
1.14 (0.92–1.41)
0.25
1.16 (0.9–1.48)
0.57
miRNA146a G>C
C/G Allelic model
CC/GG Homozygote model
CG/GG Heterozygote model
CC + CG/GG Dominant model
CC/CG + GG Recessive model
Ethnicity
Overall
1.34 (1.10–1.62)
0.001
1.56 (1.10–2.22)
0.037
1.50 (1.17–1.93)
0.081
1.54 (1.17–2.02)
0.022
1.19 (0.95–1.49)
0.062
Caucasian
1.39 (0.94–2.04)
<0.001
1.45 (0.68–3.08)
0.009
1.50 (1.00–2.24)
0.051
1.46 (0.90–2.34)
0.008
1.18 (0.72–1.92)
0.019
Asian
1.29 (1.12–1.48)
0.79
1.69 (1.27–2.24)
0.52
1.49 (1.31–1.87)
0.198
1.61 (1.24–2.08)
0.25
1.27 (1.04–1.54)
0.886
Diseases
UC
4
1.32 (1.15–1.50)
0.64
1.43 (1.06–1.93)
0.39
1.32 (1.04–1.67)
0.42
1.38 (1.10–1.73)
0.34
1.20 (0.99–1.47)
0.65
CD
3
1.37 (0.85–2.22)
0
1.94 (0.89–4.24)
0.009
1.94 (1.49–2.52)
0.15
1.79 (1.10–2.02)
0.034
1.33 (0.76–2.33)
0.006
miRNA499 A>G
G/A
GG/AA
GA/AA
GG + GA/AA
GG/GA + AA
Ethnicity
Overall
1.08 (0.96–1.22)
0.75
1.43 (1.06–1.93)
0.27
0.86 (0.56–1.33)
<0.001
0.97 (0.78–1.20)
0.06
1.28 (0.64–2.53)
0.001
Caucasian
1.08 (0.92–1.28)
0.38
1.72 (1.19–1.49)
0.24
0.62 (0.29–1.35)
<0.001
0.81 (0.66–1.00)
0.17
1.74 (0.68–4.49)
0.016
Asian
1.09 (0.91–1.30)
0.70
0.94 (0.54–1.64)
0.83
1.17 (0.94–1.46)
0.28
1.14 (0.93–1.42)
0.42
0.88 (0.51–1.51)
0.73
Diseases
UC
4
1.11 (0.96–1.29)
0.53
1.47 (1.04–2.06)
0.1
0.82 (0.41–1.63)
<0.001
0.97 (0.69–1.36)
0.02
1.19 (0.43–3.30)
0
CD
2
1.02 (0.81–1.28)
0.9
1.29 (0.67–2.5)
0.98
0.94 (0.71–1.24)
0.91
0.98 (0.75–1.27)
0.99
1.33 (0.69–2.54)
0.99
P: value with significance. : significant statistical difference among different data. PH: value with heterogeneity. PH < 0.1: significant statistical heterogeneity among various data. The random effects model should be applied; otherwise, instead, the fixed effects model should be used.
