Review Article

Crosstalk between the Tumor Microenvironment and Immune System in Pancreatic Ductal Adenocarcinoma: Potential Targets for New Therapeutic Approaches

Table 2

Current clinical trials investigating strategies directed against TME in PDAC.

Study IDSettingStudy drugsPhaseStatus

NCT02715804Metastatic PDAC
(I line—HA high pts)
Nab-P + GEM ± PEGPH20III randRecruiting
NCT02923921Metastatic PDAC (II line)FOLFOX ± AM0010III randRecruiting
NCT02436668Metastatic (I line)Nab-P + GEM ± ibrutinibII-III randActive, not recruiting
NCT02030860ResectableNab-P + GEM ± ParicalcitolII randActive, not recruiting
NCT02243371AdvancedGVAX + CY + CRS-207 ± NivolumabII randActive, not recruiting
NCT03006302MetastaticEpacadostat + Pembrolizumab + CRS-207 ± CY/GVAXII randRecruiting
NCT02648282Locally advancedCY, pembrolizumab, GVAX, and SBRTIIRecruiting
NCT01088789ResectedBoost vaccinations of pancreatic tumor cell vaccineIIRecruiting
NCT02826486MetastaticBL-8040 + PembrolizumabIIActive, not recruiting
NCT03432676AdvancedIDO-1 inhibitor + Epacadostat + Pembrolizumab in PDAC with CIS/HRDIINot yet recruiting
NCT02910882Localized, unresectablePEGPH20 + GEM + radiotherapyIIActive, not recruiting
NCT02451982ResectableGVAX + CY ± NivolumabI-II randRecruiting
NCT03193190MetastaticAtezolizumab + Cobimetinib or Atezolizumab + PEGPH20 or Atezolizumab + BL-8040I-II randRecruiting
NCT02210559Locally advancedGEM + Nab-P ± FG-3019I-II randActive, not recruiting
NCT02311361MetastaticTremelimumab and/or Durvalumab + radiation therapyI-IIRecruiting
NCT02583477MetastaticDurvalumabI-IIActive, not recruiting
NCT02305186ResectablePembrolizumabI-IIRecruiting
NCT02077881MetastaticIDO Inhibitor + Nab-P + GEMI-IIRecruiting
NCT02562898MetastaticIbrutinib + Nab-P + GEMI-IIActive, not recruiting
NCT02529579AdvancediAPA-DC/CTL + GEMI-IIRecruiting
NCT03180437Resectable/advanced/metastaticγδ T-cellI-IIRecruiting
NCT02311361UnresectableTremelimumab and/or MEDI4736 + radiation therapy+I-IIRecruiting
NCT03451773AdvancedM7824 + GEMI-IIRecruiting
NCT02713529AdvancedAMG 820 + PembrolizumabI-IIActive, not recruiting
NCT02807844MetastaticMCS110 + SpartalizumabI-IIRecruiting
NCT02929797Locally advancedGEM ± CD8 + NKG2D + AKT cellI randRecruiting
NCT03519308ResectableNivolumab + ParicalcitolIRecruiting
NCT02559674MetastaticALT-803 + Nab-P + GEMIActive, not recruiting
NCT02588443ResectableRO7009789 alone or RO7009789 + Nab-P + GEM ➔ RO7009789 + Nab-P + GEMIRecruiting
NCT02345408AdvancedCCX872-BIActive, not recruiting
NCT02550327AdvancedNab-P + GEM + Cisplatin + AnakinraIRecruiting
NCT02930902ResectablePembrolizumab + Paricalcitol ± Nab-P + GEMIRecruiting
NCT02868632Locally advancedMEDI4736 + SBRT or Tremelimumab + SBRT or MEDI4736 + Tremelimumab + SBRTIRecruiting
NCT01473940MetastaticIpilimumab + GEMIActive, not recruiting
NCT02777710MetastaticDurvalumab + PexidartinibIRecruiting
NCT02345408UnresectableCCX872-BIActive, not recruiting
NCT02045589AdvancedVCN-01 + Nab-P + GEMIActive, not recruiting
NCT03481920Advanced or locally advancedPEGPH20 + AvelumabIRecruiting
NCT02734160MetastaticGalunisertib + DurvalumabIRecruiting

rand: randomized; pts: patients; GEM: gemcitabine; Nab-P: nab-paclitaxel; CY: Cyclophosphamide; SBRT: stereotactic body radiation therapy; CIS: chromosomal instability; HRD: homologous recombination repair deficiency; ➔: followed by. PANC 10.05 pcDNA-1/GM-Neo and PANC 6.03 pcDNA-1 neo vaccine.