Diagnostic Accuracy of NICE Classification System for Optical Recognition of Predictive Morphology of Colorectal Polyps

Table 3

Diagnostic accuracy of the NICE classification system for optical recognition of colorectal polyps histology (n denotes number of polyps).

		Share of accurate diagnosis
			(%)	95% CI	OR
All polyps	735	564	(76.7)	(73.4–79.7)
Sex of the patient
Male	490	368	(75.1)	(71.0–78.9)	1
Female	245	196	(80.0)	(74.4–84.8)	1.33	0.139	>0.999
Age of patients (years)
≤44	40	34	(85.0)	(70.2–94.3)	1
45–54	81	57	(70.4)	(59.2–80.0)	0.42	0.085	>0.999
55–64	291	223	(76.6)	(71.3–81.3)	0.58	0.238	>0.999
65–74	220	169	(76.8)	(70.7–82.2)	0.59	0.254	>0.999
≥75	103	81	(78.6)	(69.4–86.1)	0.65	0.392	>0.999
Number of examined polyps per physician
Physician A	388	296	(76.3)	(71.7–80.4)	1
Physician B	114	96	(84.2)	(76.2–90.4)	1.66	0.074	>0.999
Physician C	98	80	(81.6)	(72.5–88.7)	1.38	0.260	>0.999
Physician D	37	22	(59.5)	(41.8–75.0)	0.46	0.027	0.567
Physician E	38	26	(68.4)	(51.3–82.5)	0.67	0.284	>0.999
Physician F	30	22	(73.3)	(54.1–87.7)	0.86	0.715	>0.999
Physician G	10	6	(60.0)	(26.2–87.8)	0.47	0.245	>0.999
Other physicians	20	16	(80.0)	(56.3–94.3)	1.24	0.703	>0.999
Polyp location							>0.999
Rectum	115	86	(74.8)	(65.9–82.4)	1		>0.999
Sigmoid colon	320	244	(76.3)	(71.3–80.9)	1.08	0.752	>0.999
Descending colon	65	44	(67.7)	(55.0–78.8)	0.71	0.309	>0.999
Splenic flexure	7	6	(85.7)	(42.1–99.6)	2.02	0.522	>0.999
Transverse colon	39	29	(74.4)	(57.9–87.0)	0.98	0.958	0.958
Hepatic flexure	30	28	(93.3)	(77.9–99.2)	4.72	0.042	0.840
Ascending colon	51	40	(78.4)	(64.6–88.7)	1.23	0.612	>0.999
Cecum	108	87	(80.6)	(71.9–87.6)	1.40	0.303	>0.999
Polyp size (mm)
Diminutive (1–5 mm)	336	211	(62.8)	(57.4–68.0)	1
Small (6–9 mm)	140	120	(85.7)	(78.9–91.0)	3.56	<0.001	<0.001
Large (10–20 mm)	205	185	(90.2)	(85.3–93.9)	5.48	<0.001	<0.001
Extra-large (>20 mm)	49	44	(89.8)	(77.8–96.6)	5.21	0.001	0.025
The Paris endoscopic classification
Sessile polyps (Is)	497	368	(74.0)	(69.9–77.8)	1
Pedunculated polyps (Ip)	137	121	(88.3)	(81.7–93.2)	2.65	0.001	0.024
Subpedunculated polyps (Is + Ip)	44	37	(84.1)	(69.9–93.4)	1.85	0.146	>0.999
Flat elevation of mucosa (IIa)	27	14	(51.9)	(32.0–71.4)	0.38	0.015	0.345
Flat elevation with central depression (IIa + IIc)	5	5	(100.0)	(47.8–100)	-
IIa + Iib	3	2	(66.7)	(9.4–99.2)	-
Is + Iia	2	2	(100.0)	(15.8–100)	-
The NICE classification
1	104	38	(36.5)	(27.3–46.5)	1
2	612	516	(84.3)	(81.2–87.1)	0.34	<0.001	<0.001
3	19	8	(42.1)	(28.8–75.5)	1.93	0.191	>0.999
Lesions (NICE classification)
Nonneoplastic	104	38	(36.5)	(27.3–46.5)	1
Neoplastic	631	526	(83.4)	(80.3–86.2)	8.70	<0.001	<0.001
Histopathological diagnosis
LGIEN	375	325	(86.7)	(82.8–90.0)	1
HGIEN	209	195	(93.3)	(89.9–96.3)	2.14	0.016	0.352
Hyperplastic polyp	108	36	(33.3)	(24.5–43.0)	0.08	<0.001	<0.001
Normal tissue	18	0	(0.0)	(0.0–18.5)	0.00
Invasive carcinoma	16	8	(50.0)	(24.7–75.4)	0.15	<0.001	<0.001
Other	9	0	(0.0)	(0.0–33.6)	0.00
The risk of lesions
Low (LGIEN, hyperplastic, normal tissue, and other)	510	361	(70.8)	(66.6–74.7)	1
High (HGEIN, invasive carcinoma)	225	203	(90.2)	(85.5–93.8)	3.81	<0.001	<0.001

The data is presented as the number (percent), unless otherwise indicated. 1 = reference category; OR = odds ratio; 95% CI = 95% confidence interval;  = statistical significance of appearance for accurate diagnosis;  = statistical significance corrected by sequential Holm-Bonferroni correction; - = statistics have not been calculated because of the low polyp count.