Gastroenterology Research and Practice / 2018 / Article / Tab 1

Research Article

Cyclooxygenase-2 Expression Is a Predictive Marker for Late Recurrence in Colorectal Cancer

Table 1

Clinical and pathological characteristics according to COX-2 expression in 376 patients with R0 resection.

VariableTotal patient ()COX-2 negative ()COX-2 positive () value

Age (yr)0.496
 <70311 (82.7%)134 (81.2%)177 (83.9%)
 ≥7065 (17.3%)31 (18.8%)34 (16.1%)
Gender0.436
 Male208 (55.3%)95 (57.6%)113 (53.6%)
 Female168 (44.7%)70 (42.4%)98 (46.4%)
Tumor location0.209
 Right colon82 (21.8%)34 (20.6%)48 (22.7%)
 Left colon113 (30.1%)43 (26.1%)70 (33.2%)
 Rectum181 (48.1%)88 (53.3%)93 (44.1%)
Tumor size0.961
 <5 cm118 (31.4%)52 (31.5%)66 (31.3%)
 ≥5 cm258 (68.6%)113 (68.5%)145 (68.7%)
Gross type0.297
 Fungating180 (44.9%)83 (50.3%)97 (46.0%)
 Infiltrative170 (46.9%)69 (41.8%)101 (47.8%)
 Unknown26 (8.2%)13 (7.9%)13 (6.2%)
Cell type0.303
 Nonmucinous356 (94.7%)154 (93.3%)202 (95.7%)
 Mucinous20 (5.3%)11 (6.7%)9 (4.3%)
Differentiation0.032
 WD10 (2.7%)5 (3.0%)5 (2.4%)
 MD301 (80.1%)141 (85.5%)160 (75.8%)
 PD65 (17.3%)19 (11.5%)46 (21.8%)
Lymphatic invasion0.004
 Absent180 (47.9%)65 (39.4%)115 (54.5%)
 Present196 (52.1%)100 (60.6%)96 (45.5%)
Vascular invasion0.634
 Absent372 (98.9%)164 (99.4%)208 (98.6%)
 Present4 (1.1%)1 (0.6%)3 (1.4%)
T category0.089
 T17 (1.9%)1 (0.6%)6 (2.8%)
 T232 (8.5%)9 (5.5%)23 (10.9%)
 T3330 (87.8%)152 (92.1%)178 (84.4%)
 T47 (1.9%)3 (1.8%)4 (1.9%)
N category0.019
 N0185 (49.2%)69 (41.8%)116 (55.0%)
 N190 (23.9%)41 (24.8%)49 (23.2%)
 N2101 (26.9%)55 (33.3%)46 (21.8%)
Stage0.003
 I31 (8.2%)7 (4.2%)24 (11.4%)
 II158 (42.0%)62 (37.6%)96 (45.5%)
 III187 (49.7%)96 (58.2%)91 (43.1%)
Recurrence0.001
 Early (≤3 yrs)71 (18.9%)45 (27.4%)26 (12.3%)
 Late (>3 yrs)27 (7.2%)7 (4.3%)20 (9.4%)
No278 (73.9%)112 (67.9%)166 (78.7%)

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