Cyclooxygenase-2 Expression Is a Predictive Marker for Late Recurrence in Colorectal Cancer

Table 2

Clinical and pathological characteristics according to COX-2 expression in patients with recurrence.

Variable	Total patient ()	COX-2 negative ()	COX-2 positive ()	value
Age (yr)				0.200
<70	80 (81.6%)	40 (76.9%)	40 (87.0%)
≥70	18 (18.4%)	12 (23.1%)	6 (13.0%)
Gender				0.267
Male	56 (57.1%)	27 (51.9%)	29 (63.0%)
Female	42 (42.9%)	25 (48.1%)	17 (37.0%)
Tumor location				0.725
Right colon	25 (25.5%)	13 (25.0%)	12 (26.1%)
Left colon	16 (16.3%)	9 (17.3%)	7 (15.2%)
Rectum	57 (58.2%)	30 (57.7%)	26 (58.7%)
Tumor size				0.286
<5 cm	33 (33.7%)	20 (38.5%)	13 (28.3%)
≥5 cm	65 (66.3%)	32 (61.5%)	33 (71.7%)
Gross type				0.680
Fungating	44 (44.9%)	22 (42.3%)	22 (47.8%)
Infiltrative	46 (46.9%)	25 (48.0%)	21 (45.6%)
Unknown	8 (8.2%)	5 (9.6%)	3 (6.5%)
Cell type				1.000
Nonmucinous	93 (94.9%)	49 (94.2%)	44 (95.7%)
Mucinous	5 (5.1%)	3 (5.8%)	2 (4.3%)
Differentiation				0.291
WD	4 (4.1%)	2 (3.8%)	2 (4.3%)
MD	75 (76.5%)	43 (82.7%)	32 (69.6%)
PD	19 (19.4%)	7 (13.5%)	12 (26.1%)
Lymphatic invasion				0.190
Absent	20 (20.4%)	8 (15.4%)	12 (26.1%)
Present	78 (79.6%)	44 (84.6%)	34 (73.9%)
Vascular invasion				1.000
Absent	98 (100%)	52 (100%)	46 (100%)
Present	0 (0%)	0 (0%)	0 (0%)
T category				0.840
T1	0 (0%)	0 (0%)	0 (0%)
T2	3 (3.1%)	1 (1.9%)	2 (4.3%)
T3	92 (93.9%)	49 (94.2%)	43 (93.5%)
T4	3 (3.1%)	2 (3.8%)	1 (2.2%)
N category				0.479
N0	22 (22.4%)	11 (21.2%)	11 (23.9%)
N1	27 (27.6%)	17 (32.7%)	10 (21.7%)
N2	49 (50.0%)	24 (46.2%)	25 (54.3%)
Stage				0.713
I	1 (1%)	0 (0%)	1 (2.2%)
II	22 (22.4%)	11 (21.2%)	11 (23.9%)
III	75 (76.6%)	41 (78.8%)	34 (73.9%)
Time to recurrence (month)	27.6 ± 24.8	21.9 ± 17.4	34.1 ± 30.0	0.019
Recurrence type				0.001
Early (≤3 yrs)	71 (72.4%)	45 (86.5%)	26 (56.5%)
Late (>3 yrs)	27 (27.6%)	7 (13.5%)	20 (43.5%)