Gastroenterology Research and Practice / 2018 / Article / Tab 2

Research Article

Cyclooxygenase-2 Expression Is a Predictive Marker for Late Recurrence in Colorectal Cancer

Table 2

Clinical and pathological characteristics according to COX-2 expression in patients with recurrence.

VariableTotal patient ()COX-2 negative ()COX-2 positive () value

Age (yr)0.200
 <7080 (81.6%)40 (76.9%)40 (87.0%)
 ≥7018 (18.4%)12 (23.1%)6 (13.0%)
Gender0.267
 Male56 (57.1%)27 (51.9%)29 (63.0%)
 Female42 (42.9%)25 (48.1%)17 (37.0%)
Tumor location0.725
 Right colon25 (25.5%)13 (25.0%)12 (26.1%)
 Left colon16 (16.3%)9 (17.3%)7 (15.2%)
 Rectum57 (58.2%)30 (57.7%)26 (58.7%)
Tumor size0.286
 <5 cm33 (33.7%)20 (38.5%)13 (28.3%)
 ≥5 cm65 (66.3%)32 (61.5%)33 (71.7%)
Gross type0.680
 Fungating44 (44.9%)22 (42.3%)22 (47.8%)
 Infiltrative46 (46.9%)25 (48.0%)21 (45.6%)
 Unknown8 (8.2%)5 (9.6%)3 (6.5%)
Cell type1.000
 Nonmucinous93 (94.9%)49 (94.2%)44 (95.7%)
 Mucinous5 (5.1%)3 (5.8%)2 (4.3%)
Differentiation0.291
 WD4 (4.1%)2 (3.8%)2 (4.3%)
 MD75 (76.5%)43 (82.7%)32 (69.6%)
 PD19 (19.4%)7 (13.5%)12 (26.1%)
Lymphatic invasion0.190
 Absent20 (20.4%)8 (15.4%)12 (26.1%)
 Present78 (79.6%)44 (84.6%)34 (73.9%)
Vascular invasion1.000
 Absent98 (100%)52 (100%)46 (100%)
 Present0 (0%)0 (0%)0 (0%)
T category0.840
 T10 (0%)0 (0%)0 (0%)
 T23 (3.1%)1 (1.9%)2 (4.3%)
 T392 (93.9%)49 (94.2%)43 (93.5%)
 T43 (3.1%)2 (3.8%)1 (2.2%)
N category0.479
 N022 (22.4%)11 (21.2%)11 (23.9%)
 N127 (27.6%)17 (32.7%)10 (21.7%)
 N249 (50.0%)24 (46.2%)25 (54.3%)
Stage0.713
 I1 (1%)0 (0%)1 (2.2%)
 II22 (22.4%)11 (21.2%)11 (23.9%)
 III75 (76.6%)41 (78.8%)34 (73.9%)
Time to recurrence (month)27.6 ± 24.821.9 ± 17.434.1 ± 30.00.019
Recurrence type0.001
 Early (≤3 yrs)71 (72.4%)45 (86.5%)26 (56.5%)
 Late (>3 yrs)27 (27.6%)7 (13.5%)20 (43.5%)

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