Cyclooxygenase-2 Expression Is a Predictive Marker for Late Recurrence in Colorectal Cancer

Table 3

Univariate and multivariate analysis of independent risk factors associated with late recurrence.

Variable	Early recurrence (<3 yr) ()	Late recurrence (≥3 yr) ()	Univariate analysis ( value)	Multivariate analysis (OR, 95% CI, value)
Age (yr)			0.382
<70	56 (78.9%)	24 (88.9%)
≥70	15 (21.1%)	3 (11.1%)		0.726 (0.174–3.024) 0.660
Gender			0.473
Male	39 (54.9%)	17 (63.0%)		0.996 (0.361–2.747) 0.993
Female	32 (45.1%)	10 (37.0%)
Tumor location			1.000
Right colon	18 (25.3%)	7 (25.9%)
Left colon	12 (16.9%)	4 (14.8%)
Rectum	41 (57.7%)	16 (59.3%)
Tumor size			0.965
<5 cm	24 (33.8%)	9 (33.3%)
≥5 cm	47 (66.2%)	18 (66.7%)
Gross type			0.280
Fungating	30 (42.3%)	14 (51.9%)
Infiltrative	36 (50.7%)	10 (37.0%)
Unknown	5 (7.0%)	3 (11.1%)
Cell type			0.614
Nonmucinous	68 (95.8%)	25 (92.6%)
Mucinous	3 (4.2%)	2 (7.4%)
Differentiation			0.818
WD	3 (4.2%)	1 (3.7%)
MD	53 (74.6%)	22 (81.5%)
PD	15 (21.1%)	4 (14.8%)
Lymphatic invasion			0.012
Absent	10 (14.1%)	10 (37.0%)
Present	61 (85.9%)	17 (63.0%)		0.309 (0.103–0.924) 0.036
Vascular invasion			1.000
Absent	71 (100%)	27 (100%)
Present	0 (0%)	0 (0%)
T category			0.193
T1	0 (0%)	0 (0%)
T2	1 (1.4%)	2 (7.4%)
T3	67 (94.4%)	25 (92.6%)
T4	3 (4.2%)	0 (0%)
N category			0.102
N0	12 (16.9%)	10 (37.0%)
N1	21 (29.6%)	6 (22.3%)
N2	38 (53.5%)	11 (40.7%)
Stage			0.051
I	0 (0%)	1 (3.7%)
II	13 (18.3%)	9 (33.3%)
III	58 (81.7%)	17 (63.0%)		1.315 (0.256–6.753) 0.743
COX-2 expression			0.001
Negative	45 (63.4%)	7 (25.9%)
Positive	26 (36.6%)	20 (74.1%)		4.656 (1.696–12.779) 0.003