Figure 2: Middle hepatic vein blood flow index measured by transesophageal echocardiography. Box and whisker diagram of middle hepatic vein blood flow index expressed in ml/min/m2. Whisker extremities are maximum and minimum, boxes are interquartile ranges between the 75th and 25th percentiles, and the segment inside the box is the median of the sample. value < 0.001 results from a Friedman’s two-way analysis of variance by rank. The indicates a significantly different value compared to baseline with the Wilcoxon signed-rank test. Time 0: after induction of general anaesthesia, before starting epidural analgesia. Time 1: 30 min after beginning epidural analgesia. Time 2: end of CRS, before abdominal filling. Time 3: end of HIPEC, before abdominal emptying. Time 4: end of procedure, after abdominal emptying and removal of abdominal drainage.