White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner

Table 4

Multivariate analyses examining the association between clinical characteristics and survival in pancreatic cancer patients.

Characteristics	(%)	HR	95% CI	value
Gender
Female	77 (36.0%)	1	Reference
Male	137 (64.0%)	1.277	0.896–1.821	0.177
Age
≤60	101 (47.2%)	1	Reference
>60	113 (52.8%)	0.763	0.549–1.062	0.109
Locations
Head	81 (37.9%)	1	Reference
Body/tail	133 (62.1%)	1.384	0.980–1.954	0.065
TNM classification
Stage 3	83 (38.8%)	1	Reference
Stage 4	131 (61.2%)	0.888	0.622–1.267	0.512
Baseline WBC
<5.8 × 10^9/L	107 (50%)	1	Reference
≥5.8 × 10^9/L	107 (50%)	1.808	1.055–3.096	0.031
Baseline granulocyte
<3.7 × 10^9/L	106 (49.5%)	1	Reference
≥3.7 × 10^9/L	108 (50.5%)	7.346	1.275–42.321	0.026
Baseline neutrophil
<3.9 × 10^9/L	104 (48.6%)	1	Reference
≥3.9 × 10^9/L	110 (51.4%)	4.682	0.772–28.394	0.093
Baseline lymphocyte
<1.4 × 10^9/L	123 (57.5%)	1	Reference
≥1.4 × 10^9/L	91 (42.5%)	0.678	0.444–1.037	0.073
Baseline NLR
<2.8	105 (49.1%)	1	Reference
≥2.8	109 (50.9%)	1.435	0.913–2.257	0.117
Baseline PLR
<124.6	107 (50%)	1	Reference
≥124.6	107 (50%)	1.078	0.752–1.546	0.683

Note: the multivariate Cox regression model adjusted for gender, age, location, TNM classification, WBC, granulocyte, neutrophil, lymphocyte, NLR, and PLR. HR: hazard ratio; CI: confidence interval; WBC: white blood cell; NLR: neutrophil-to-lymphocyte ratio; PLR: platelet-to-lymphocyte ratio.