Statin Use and Cancer Incidence in Patients with Type 2 Diabetes Mellitus: A Network Meta-Analysis

Table 1

Characteristics of included studies in this network meta-analysis.

First author	Year	Country/district	Study period	Number of patients	Cancer types	ICD	Research types	Statin types	Quality of scores
Chen [34]	2015	Taiwan	2000–2010	2053	Hepatocellular carcinoma	ICD-9-CN: 155	Case-control study	a, b, c, d, e, f	8/9
El–Serag [35]	2009	United States	1997–2002	3302	Hepatocellular carcinoma	ICD-9-CM: 155	Case-control study	a	8/9
Lee [37]	2012	Korea	1999–2008	1920	Gastric cancer	ICD: 16.0–16.9	Case-control study	a, b, c, f, g	8/9
Beishuizen [36]	2004	Netherlands	2001–2003	182	Malignancies	/	RCT	a	5
Wanner [38]	2005	Germany	1998–2004	1255	Cancer	/	RCT	b	5
Kim [39]	2016	Korea	2002–2013	154	Hepatocellular carcinoma	ICD C22.0	Case-control study	a, b, c, d, e, f, g	8/9
Hachem [40]	2009	United States	1997–2002	14,707	Colorectal cancer	ICD-9: 153.0–153.9154.0–154.1154.8230.3230.4	Case-control study	a	8/9

RCT: randomized controlled trial; /: there is no record of the ICD of cancer; ICD: international classification of disease; a: simvastatin; b: atorvastatin; c: pravastatin; d: fluvastatin; e: lovastatin; f: rosuvastatin, g: pitavastatin.