Review Article
Diagnostic Value of CA 19-9 and Carcinoembryonic Antigen for Pancreatic Cancer: A Meta-Analysis
Table 2
Subgroup based on different cutoff values of CA 19-9 and CEA.
| Outcomes | Group | Ratio of indices and 95% CI | value | Heterogeneity (%) | value for heterogeneity | Ratio between subgroups |
| Sensitivity | Cutoff value of CA 19-9 | 37 U/ml | 1.46 (1.25–1.70) | <0.001 | 70.1 | <0.001 | 0.55 (0.35–0.87)/0.011 | Others | 2.65 (1.72–4.08) | <0.001 | 0.0 | 0.977 | Cutoff value of CEA | 5 ng/ml | 1.59 (1.29–1.96) | <0.001 | 75.9 | <0.001 | 1.10 (0.74–1.64)/0.624 | Others | 1.44 (1.03–2.02) | 0.034 | 52.9 | 0.120 |
| Specificity | Cutoff value of CA 19-9 | 37 U/ml | 1.00 (0.92–1.10) | 0.945 | 67.5 | 0.001 | 1.19 (1.04–1.36)/0.011 | Others | 0.84 (0.76–0.93) | <0.001 | 0.0 | 0.673 | Cutoff value of CEA | 5 ng/ml | 0.96 (0.86–1.06) | 0.412 | 69.8 | <0.001 | 0.94 (0.79–1.12)/0.498 | Others | 1.02 (0.89–1.18) | 0.757 | 73.1 | 0.024 |
| DOR | Cutoff value of CA 19-9 | 37 U/ml | 3.55 (2.16–5.83) | <0.001 | 49.8 | 0.030 | 1.15 (0.29–4.57)/0.848 | Others | 3.10 (0.85–11.25) | 0.086 | 38.6 | 0.202 | Cutoff value of CEA | 5 ng/ml | 3.81 (2.56–5.67) | <0.001 | 0.0 | 0.451 | 1.27 (0.23–7.16)/0.786 | Others | 3.00 (0.56–16.21) | 0.202 | 84.3 | 0.002 |
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