Interobserver Agreement in the Diagnosis of Inflammatory Bowel Disease-Associated Neoplasia in China in Comparison to Subspecialized American Gastrointestinal Pathologists

<div>One colonic biopsy with a consensus diagnosis of high-grade dysplasia by US pathologists was read as low-grade dysplasia by two Chinese pathologists (a) (H&amp;E, 200x). The dysplastic glands had very bland nuclear features but a complex cribriform architecture, thus was interpreted as high-grade dysplasia by US pathologists. Another example of colonic biopsy with a consensus diagnosis of low-grade dysplasia by US pathologists was read as high-grade dysplasia by three Chinese pathologists (b) (H&amp;E, 200x). The dysplastic glands had maintained nuclear polarity and without obvious nuclear pleomorphism. The architecture was focally complex with impending cribriform glands, but was regarded within the low-grade dysplasia spectrum by US pathologists.</div>

Gastroenterology Research and Practice

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Figure 2: Interobserver Agreement in the Diagnosis of Inflammatory Bowel Disease-Associated Neoplasia in China in Comparison to Subspecialized American Gastrointestinal Pathologists 

Figure 2 | Interobserver Agreement in the Diagnosis of Inflammatory Bowel Disease-Associated Neoplasia in China in Comparison to Subspecialized American Gastrointestinal Pathologists 