|
| Features | Definition | Score/code |
|
| Surface maturation | | |
| Absent | The size and staining quality of surface and crypt basal nucleus are identical. | 0 |
| Present | The surface nucleus is smaller and stains paler than the crypt basal nucleus. | 1 |
| Nuclear enlargement | | |
| Absent | The nucleus of interest is of normal size or similar to nearby nonneoplastic epithelial nucleus. | 0 |
| Present | The nucleus of interest is larger than nearby nonneoplastic epithelial nucleus. | 1 |
| Nuclear hyperchromasia | | |
| Absent | The nucleus of interest has similar staining quality similar to adjacent nonneoplastic epithelial nucleus. | 0 |
| Present | The nucleus of interest stains darker than normal or darker than adjacent nonneoplastic epithelial nucleus. | 1 |
| Nuclear stratification | | |
| Absent | The nucleus is not overlapping with each other, and there is a single layer of nuclei in the glandular lining epithelium. | 0 |
| Present, only involving the basal half of the crypt epithelium | The nucleus shows overlapping with each other, more than single layer of nuclei in the glandular lining epithelium, but occupying the basal half of the glandular epithelium thickness. | 1 |
| Present, reaching more than half way to the crypt epithelium | The nucleus shows overlapping with each other, more than single layer of nuclei in the glandular lining epithelium, and reaching more than half way to the glandular epithelium thickness. | 2 |
| Nuclear pleomorphism | | |
| Absent | The nucleus of interest has uniform size and shape. | 0 |
| Present | The nucleus of interest has different size and shape. | 1 |
| Loss of nuclear polarity | | |
| Absent | The long axis of the nucleus is perpendicular to the basement membrane and arranged paralleling to each other. | 0 |
| Present | The long axis of the nucleus is no longer perpendicular to the basement membrane and arranged in a haphazard way with each other. | 1 |
| Architectural complexity | | |
| Absent | Small straight glands. | 0 |
| Present, cribriform | Gland-in-gland. | 1 |
| Present, papillary | Papillary structure on the surface and/or in the lumen of the glands. | 2 |
| Present, cribriform and papillary | Both cribriform and papillary structures present. | 3 |
| Abnormal mitosis | | |
| Absent | Only normal mitosis seen. | 0 |
| Present | Mitosis with three or more poles. | 1 |
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