Interobserver Agreement in the Diagnosis of Inflammatory Bowel Disease-Associated Neoplasia in China in Comparison to Subspecialized American Gastrointestinal Pathologists

Table 4

Diagnostic use of each feature in the diagnosis of colitis-associated dysplasia (CAD) (negative versus other).

Features in the diagnosis of CAD	Negative versus other
	Sen (%)	Spe (%)	PPV (%)	NPV (%)
Surface maturation
Reviewer 1	100	93.33	93.33	100
Reviewer 2	100	100	100	100
Reviewer 3	96.55	100	100	95.45
Reviewer 4	93.10	95.24	96.43	90.91
Nuclear enlargement
Reviewer 1	100	31.82	65.12	100
Reviewer 2	89.66	76.19	83.87	84.21
Reviewer 3	96.55	66.67	80	93.33
Reviewer 4	100	61.90	78.38	100
Hyperchromasia
Reviewer 1	92.86	40.91	66.67	81.82
Reviewer 2	93.10	42.86	69.23	81.82
Reviewer 3	96.55	66.67	80.00	93.33
Reviewer 4	100	52.38	74.36	100
Nuclear stratification
Reviewer 1	96.43	90.91	93.10	95.24
Reviewer 2	96.55	47.62	71.79	90.91
Reviewer 3	100	71.43	82.86	100
Reviewer 4	100	71.43	82.86	100