Interobserver Agreement in the Diagnosis of Inflammatory Bowel Disease-Associated Neoplasia in China in Comparison to Subspecialized American Gastrointestinal Pathologists
Table 5
Diagnostic use of each feature in the diagnosis of colitis-associated high-grade dysplasia HGD or carcinoma.
Features in the diagnosis of colitis-associated HGD or carcinoma
HGD and carcinoma versus others
Sen (%)
Spe (%)
PPV (%)
NPV (%)
Nuclear pleomorphism
Reviewer 1
75
100
100
95.45
Reviewer 2
50
97.73
75
93.48
Reviewer 3
100
100
100
100
Reviewer 4
100
100
100
100
Loss of polarity
Reviewer 1
75
100
100
95.45
Reviewer 2
83.33
100
100
97.78
Reviewer 3
100
100
100
100
Reviewer 4
100
100
100
100
Nuclear pleomorphism or loss of polarity
Reviewer 1
75
100
100
95.45
Reviewer 2
83.33
97.73
83.33
97.73
Reviewer 3
100
100
100
100
Reviewer 4
100
100
100
100
Cribriform architecture
Reviewer 1
62.5
100
100
93.33
Reviewer 2
100
100
100
100
Reviewer 3
100
97.83
80.00
100
Reviewer 4
60
95.56
60
95.56
Nuclear pleomorphism or loss of polarity or cribriform
Reviewer 1
100
100
100
100
Reviewer 2
100
97.73
85.71
100
Reviewer 3
100
100
100
100
Reviewer 4
100
84.85
71.43
100
Nuclear stratification reaching more than half way of the crypt epithelium
