Activation of Signal Transduction and Activator of Transcription 3 Signaling Contributes to Helicobacter-Associated Gastric Epithelial Proliferation and Inflammation

Figure 1

Mouse model of infection and H&E staining of the mouse gastric mucosa. (a) Eight-week-old mice were infected with H. felis three times every other day and were euthanized at 18 months postinfection. (b) Uninfected control mice with WT and Stat3^Δgec mice were sacrificed at 18 months ( each). WT and Stat3^Δgec mice infected with H. felis for 18 months ( WT and Stat3^Δgec). Representative H&E-stained images are shown (magnification ×100, scale bar 100 μm). (c) Histological scores at 18 months postinfection. Each parameter was scored on an ordinal scale from 0 to 4 ().

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