Activation of Signal Transduction and Activator of Transcription 3 Signaling Contributes to Helicobacter-Associated Gastric Epithelial Proliferation and Inflammation

Figure 5

Contribution of STAT3 signaling to the proliferation in gastric stem/progenitor cells. (a) Expression of intestinal metaplasia-associated genes in gastric organoids of Stat3^Δgec or WT mice treated after stimulation with recombinant IL-6 or IL-11 () ( organoids of WT mice, organoids of Stat3^Δgec mice). (b) Expression of intestinal metaplasia-associated genes in gastric organoids treated with or without a JAK inhibitor after stimulation with recombinant IL-6 or IL-11 () ( each). (c) Immunohistochemistry for CD44v6 in WT and Stat3^Δgec mice infected with H. felis for 18 months (magnification ×200, scale bar 50 μm). (d) Number of CD44v6-positive cells per gland in Stat3^Δgec and WT mice at 18 months postinfection (). Uninfected mice were used as controls ( glands each).

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