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Gastroenterology Research and Practice
Volume 2018, Article ID 9189062, 10 pages
Review Article

Effects of Late Evening Snack on Cirrhotic Patients: A Systematic Review and Meta-Analysis

Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China

Correspondence should be addressed to Zi-bin Tian; moc.361@nusbznait and Xue Jing; moc.anis@7607xj

Received 20 October 2017; Revised 11 February 2018; Accepted 6 March 2018; Published 1 April 2018

Academic Editor: Riccardo Casadei

Copyright © 2018 Ying-jie Guo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Energetic effects of late evening snack (LES) on cirrhotic patients were reported recently, but there was no quantitative analysis. In this meta-analysis, we reviewed and quantified the effects of LES on energy metabolism and substrate oxidation in the patients with cirrhosis, which will be of benefit for liver cirrhosis nutritional therapy. Methods. A systematic search was conducted in PubMed, Embase, Web of Science, Elsevier, China National Knowledge Infrastructure, and Wanfang Database for relevant trials published until July 2017. These studies statistically were combined and analyzed by RevMan 5.3. Results. Fourteen trials comprising 478 cases were eligible for analysis. The results showed that the respiratory quotient value (MD = 11.09) and carbohydrate oxidation value (MD = 0.05) significantly elevated with one week or with up to three weeks of LES treatment in cirrhotic patients (). Meanwhile, the levels of serum albumin (MD = 2.98) and cholinesterase (SMD = 1.09) were increased with LES administration for three weeks or that lasting twelve weeks (). However, there was no significant improvement for the levels of alanine aminotransferase (ALT) (), aspartate aminotransferase (AST) (), and total bilirubin (TB) (). Conclusions. LES could improve the energy malnutrition state of cirrhotic patients. However, it may have little effect on reducing liver parenchymal injury indexes such as serum aminotransferase.