|
| Author | Trials | Probiotic | Result |
|
| Jian et al. [37] | 8 RCT () | Lactobacilli + triple therapy | Pooled eradication rate
Probiotic: 82.26% (95% CI = 78.01–86.51%)
No probiotic: 76.97% (95% CI = 73.11–80.83%)
OR = 1.78 (95% CI = 1.21–2.62) |
| Sachdeva and Nagpal [38] | 10 RCT () | Multistrain (fermented milk) + triple or quadruple therapy | Eradication rates were improved by approximately 5–15%
OR = 1.91 (95% CI: 1.38–2.67) |
| Dang et al.[39] | 33 RCT (), 9 RCT for children, 24 RCT for adults | Probiotics + triple therapy or sequential therapy or quadruple therapy | The pooled eradication rate in probiotic supplementation groups was significantly higher than that in controls (RR = 1.122, 95% CI = 1.086–1.159) |
| Szajewska et al.[40] | 9 RCT (adult, )
2 RCT (children, ) | Saccharomyces boulardii + triple therapy | Eradication rate (adult)
Probiotic: 80.0% (95% CI = 77–82)
No probiotic: 71.0% (95% CI = 68–74)
RR = 1.11, 95% CI = 1.06–1.17
Eradication rate (children)
Probiotic: 87.5%
No probiotic:77.2%
RR = 1.13, 95% CI = 1.03–1.25 |
| Zhang et al. [41] | 45 RCT () | Probiotics + standard therapy | Eradication rate
Probiotic: 82.31%
No probiotics: 72.08% (RR: 1.11; 95% CI: 1.08–1.15)
Side effects (RR = 0.59; 95% CI = 0.48–0.71)
Probiotic: 21.44%
No probiotic: 36.27% |
| Wen et al. [42] | 17 RCT in Asian pediatric patients () | Multistrain probiotics + 14-day triple therapy | Bifidobacterium infantis + Clostridium butyricum was most beneficial for eradication rates (RR: 1.16, 95% CI: 1.07–1.26) |
| Losurdo et al. [43] | 7 RCT () | Probiotic strain alone | The mean weighted eradication rate was 14% (95% CI = 2%–25%)
Lactobacilli: 16% (95% CI: 1%–31%)
Saccharomyces boulardii: 12% (95% CI: 0%–29%)
Multistrain: 14% (95% CI: 0%–43%) |
|
