Review Article
Prognostic and Clinicopathological Significance of MUC Family Members in Colorectal Cancer: A Systematic Review and Meta-Analysis
Table 2
Meta-analysis of the correlation between MUC expression and clinicopathological factors of colorectal cancer.
| | Clinicopathological parameter | Mucins phenotype | No. of studies | OR (95% CI) | Analysis model | Test for overall effect | Heterogeneity | | test | value | (%) | value |
| | TNM stage (III/IV vs. I/II) | MUC1 | 11 | 2.17 (1.31-3.59) | Random | 3.03 | 0.002 | 83 | <0.00001 | | MUC2 | 7 | 0.52 (0.36-0.76) | Random | 3.35 | 0.0008 | 52 | 0.05 | | MUC5AC | 8 | 1.00 (0.67-1.49) | Random | 0.01 | 0.99 | 55 | 0.03 |
| | Depth of invasion (T3/T4 vs. T1/T2) | MUC1 | 11 | 1.79 (1.41-2.26) | Fixed | 4.86 | <0.00001 | 40 | 0.08 | | MUC2 | 6 | 0.65 (0.37-1.13) | Random | 1.53 | 0.13 | 63 | 0.02 | | MUC5AC | 4 | 0.64 (0.35-1.18) | Random | 1.42 | 0.15 | 61 | 0.05 |
| | Lymph node metastasis (+ vs. -) | MUC1 | 10 | 2.45 (1.38-4.35) | Random | 3.07 | 0.002 | 81 | <0.00001 | | MUC2 | 8 | 0.59 (0.47-0.73) | Fixed | 4.64 | <0.00001 | 48 | 0.06 | | MUC5AC | 7 | 1.07 (0.67-1.72) | Random | 0.29 | 0.77 | 67 | 0.006 |
| | Tumor site (colon vs. rectum) | MUC1 | 7 | 0.79 (0.63-0.98) | Fixed | 2.12 | 0.03 | 0 | 0.63 | | MUC2 | 5 | 1.64 (1.01-2.67) | Random | 2.02 | 0.04 | 55 | 0.06 | | MUC5AC | 6 | 1.97 (1.48-2.62) | Fixed | 4.63 | <0.00001 | 49 | 0.08 |
| | Distant metastasis (+ vs. -) | MUC1 | 3 | 2.47 (1.47-4.13) | Fixed | 3.43 | 0.0006 | 49 | 0.14 | | MUC2 | 3 | 0.83 (0.48-1.41) | Fixed | 0.70 | 0.49 | 0 | 0.61 | | MUC5AC | 2 | 0.86 (0.15-4.87) | Random | 0.17 | 0.87 | 73 | 0.06 |
| | Lymphatic invasion (+ vs. -) | MUC1 | 5 | 3.39 (1.69-9.14) | Random | 3.19 | 0.001 | 72 | 0.007 | | MUC2 | 3 | 0.53 (0.27-1.03) | Random | 1.88 | 0.06 | 60 | 0.08 | | MUC5AC | 4 | 0.76 (0.55-1.05) | Fixed | 1.64 | 0.10 | 20 | 0.29 |
| | Mucinous component (high vs. low) | MUC1 | 7 | 0.71 (0.42-1.19) | Random | 1.31 | 0.19 | 59 | 0.02 | | MUC2 | 2 | 14.46 (1.71-121.97) | Random | 2.46 | 0.01 | 59 | 0.12 | | MUC5AC | 3 | 1.41 (0.85-2.34) | Fixed | 1.32 | 0.19 | 0 | 0.62 |
| | Gender (male vs. female) | MUC1 | 7 | 1.10 (0.86-1.41) | Fixed | 0.77 | 0.44 | 0 | 0.75 | | MUC2 | 7 | 0.87 (0.68-1.12) | Fixed | 1.07 | 0.29 | 8 | 0.29 | | MUC5AC | 6 | 0.93 (0.69-1.24) | Random | <0.00001 | 1.00 | 55 | 0.005 |
| | Tumor size (large vs. small) | MUC1 | 4 | 0.77 (0.53-1.12) | Fixed | 1.38 | 0.17 | 19 | 0.30 | | MUC2 | 2 | 0.70 (0.47-1.05) | Fixed | 1.73 | 0.08 | 0 | 0.39 | | MUC5AC | 2 | 0.80 (0.48-1.32) | Fixed | 0.87 | 0.38 | 0 | 0.41 |
| | Histological grade (3 vs. 1 and 2) | MUC1 | 12 | 1.39 (0.87-2.21) | Random | 1.39 | 0.16 | 66 | 0.0007 | | MUC2 | 7 | 0.75 (0.56-0.99) | Fixed | 2.02 | 0.04 | 44 | 0.10 | | MUC5AC | 5 | 1.44 (0.70-2.97) | Random | 0.99 | 0.32 | 79 | 0.0007 |
|
|
RR: risk ratio; Random: random effects model; Fixed: fixed.
|
