Prognostic and Clinicopathological Significance of MUC Family Members in Colorectal Cancer: A Systematic Review and Meta-Analysis

Table 3

Results of meta-regression analysis exploring the source of heterogeneity with OS and DFS/RFS.

Mucins phenotype	Covariates	Univariate analysis (OS)				Univariate analysis (DFS)
		Coefficient	SE	value	Coefficient	SE	value
MUC1	Antibody	0.055	0.087	0.538	-0.142	0.882	0.883
	Cut-off value	0.0297	0.032	0.369	0.155	0.295	0.635
	TNM stage	0.365	0.324	0.281	0.773	1.106	0.535
	Country	0.048	0.462	0.323	0.155	0.295	0.635
	Year	-0.001	0.014	0.964	-0.077	0.115	0.552
MUC2	Antibody	-0.204	0.215	0.367	0.550	0.252	0.094
	Cut-off value	-0.027	0.043	0.552	-0.030	0.221	0.898
	TNM stage	-0.309	0.124	0.054	-0.270	0.838	0.763
	Country	0.007	0.048	0.891	0.180	0.050	0.023
	Year	0.036	0.030	0.264	0.108	0.030	0.022
MUC5AC	Antibody	0.464	0.269	0.135	-0.139	0.434	0.769
	Cut-off value	0.187	0.158	0.282	-0.248	0.193	0.288
	TNM stage	0.923	0.211	0.055	-0.652	0.961	0.546
	Country	0.250	0.240	0.339	-0.379	0.293	0.287
	Year	0.135	0.073	0.859	0.102	0.069	0.236