Research Article
Mutation Profiling of Premalignant Colorectal Neoplasia
Table 2
Number of nonsynonymous mutations with percentages in different groups.
values are given for the results of the Cochran-Armitage trend test.
(a) |
| | Gene | LGD, (%) | LGD-H, (%) | HGD, (%) | AC, (%) | Mean (%) | value |
| | APC | 15 (78.9) | 14 (66.7) | 23 (82.1) | 13 (76.5) | 76.5 | 0.785 | | KRAS | 8 (42.1) | 15 (71.4) | 23 (82.1) | 7 (41.1) | 62.4 | 0.640 | | SYNE1 | 8 (42.1) | 6 (28.6) | 8 (28.6) | 8 (47.1) | 35.3 | 0.994 | | NOTCH4 | 4 (21.1) | 5 (23.8) | 8 (28.6) | 3 (17.6) | 23.5 | 0.858 | | TCF7L2 | 1 (5.3) | 6 (28.6) | 6 (21.4) | 3 (17.6) | 18.8 | 0.441 | | GNAS | 4 (21.1) | 2 (9.5) | 8 (28.6) | 1 (5.9) | 17.6 | 0.561 | | FBXW7 | 7 (36.8) | 1 (4.8) | 4 (14.3) | 1 (5.9) | 15.3 | 0.029 | | TAF1L | 4 (21.1) | 1 (4.8) | 5 (17.9) | 3 (17.6) | 15.3 | 0.903 | | MLL2/KMT2D | 5 (26.3) | 3 (14.3) | 1 (3.6) | 3 (17.6) | 15.33 | 0.226 | | BCL2 | 1 (5.3) | 2 (9.5) | 3 (10.7) | 5 (29.4) | 12.9 | 0.047 | | MLL3/KMT2C | 1 (5.3) | 2 (9.5) | 4 (14.3) | 3 (17.6) | 11.8 | 0.205 | | PKHD1 | 4 (21.1) | 1 (4.8) | 4 (14.3) | 1 (5.9) | 11.8 | 0.326 | | RNF213 | 3 (15.8) | 1 (4.8) | 4 (14.3) | 1 (5.9) | 10.6 | 0.601 | | CSMD3 | 1 (5.3) | 4 (19.0) | 3 (10.7) | 1 (5.9) | 10.6 | 0.836 |
|
|
(b) |
| | Gene | LGD, (%) | LGD-H, (%) | HGD, (%) | AC, (%) | Mean (%) | value |
| | TP53 | 0 | 5 (23.8) | 6 (21.4) | 6 (35.3) | 20.0 | 0.015 | | BLNK | 2 (10.5) | 9 (42.9) | 0 | 4 (23.5) | 17.6 | 0.666 | | HNF1A | 7 (36.8) | 2 (9.5) | 2 (7.1) | 0 | 12.9 | 0.001 | | LRP1B | 0 | 2 (9.5) | 4 (14.3) | 3 (17.6) | 10.6 | 0.067 |
|
|
LGD: low-grade dysplasia; HGD: high-grade dysplasia; LGD-H: low-grade dysplasia adjacent to areas of high-grade dysplasia and/or carcinoma; AC: adenocarcinoma.
|
