Mutation Profiling of Premalignant Colorectal Neoplasia

Table 3

Random forest classifier results for different groups with a decrease in accuracy for each group, values computed by the rfPermute package, and a mean decrease in accuracy for overall classification.

Gene	LGD: decrease in accuracy	LGD: value	HGD: decrease in accuracy	HGD: value	AC: decrease in accuracy	AC: value	Mean decrease in accuracy	Mean decrease in accuracy: value
KRAS	4.320	0.050	15.685	0.010	2.391	0.139	13.029	0.010
HNF1A	8.091	0.030	9.131	0.020	5.828	0.030	11.724	0.020
TP53	7.991	0.030	-2.460	0.772	2.618	0.109	5.094	0.069
FBXW7	2.640	0.168	8.457	0.030	4.272	0.050	8.780	0.040
TCF7L2	4.941	0.050	4.758	0.050	2.637	0.149	6.294	0.040
MLL2/KMT2D	1.191	0.238	7.749	0.030	-0.198	0.426	5.456	0.059
BCL2	0.359	0.337	5.242	0.059	3.657	0.109	6.076	0.030
RARA	1.728	0.188	2.823	0.337	5.263	0.050	5.458	0.109
SYNE	-0.621	0.535	6.495	0.040	-2.310	0.812	3.814	0.178

LGD: low-grade dysplasia; HGD: high-grade dysplasia; AC: adenocarcinoma.