Research Article
Perianal Paget’s Disease: The 17-Year-Experience of a Single Institution in Taiwan
Table 1
Patient demographics, pathology, PPD recurrence, synchronous or metachronous malignancies, survival, and immunophenotypes of primary perianal Paget’s diseasea.
| Case | Age (years) | Sex | Surgical treatment | Metachronous malignancy | PPD recurrence | Survival and follow-up | Cause of death | CK7 (7/10) | CK20 (6/10) | CDX2 (6/10) | GCDFP-15 (3/10) |
| 1 | 69 | M | APR | Cholangiocarcinoma (metachronous, 11 years) | None | Death, 11 years | Cholangiocarcinoma | - | + | + | - | 2 | 83 | F | WLE | None | None | Alive, 11 years | None | - | + | + | - | 3 | 76 | M | WLE | None | None | Death, 2 months | Sepsis | + | - | - | + | 4 | 75 | M | WLE | None | Yes, 1 year later | Death, 2 years | Unknown (died after discharge) | - | + | + | - | 5 | 87 | F | WLE | None | None | Death, 4 years | Respiratory failure | + | F | + | - | 6 | 77 | M | WLE | None | None | Death, 9 years | Respiratory failure | + | - | F | - | 7 | 85 | M | WLE | None | None | Death, 7 years | Unknown (died after discharge) | F | + | + | - | 8 | 62 | F | WLE | Urothelial carcinoma (metachronous, 2 years) | None | Death, 3 years | Urothelial carcinoma with multiple metastases | + | - | - | - | 9 | 60 | F | WLE then APR | None | Yes, 4 years later | Death, 6 years | DOD, PPD with lymph nodes and lung metastases | + | + | - | + | 10 | 69 | M | WLE | Rectal small-cell carcinoma (metachronous, 3 years) | None | Death, 3 years | Rectal small-cell carcinoma with lymph node metastases | + | - | - | + |
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aF: focally positive. PPD: perianal Paget’s disease; APR: abdominal peritoneal resection; WLE: wide local excision; DOD: died of disease.
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