Perianal Paget’s Disease: The 17-Year-Experience of a Single Institution in Taiwan

Table 2

Patient demographics, pathology, PPD recurrence, synchronous or metachronous malignancies, survival, and immunophenotypes of secondary perianal Paget’s disease^a.

Case	Age (years)	Sex	Surgical treatment	Continuous lesion or synchronous malignancy	PPD recurrence	Survival and follow-up	Cause of death	CK7 (6/13)	CK20 (10/13)	CDX2 (12/13)	GCDFP-15 (0/13)
11	72	F	APR	Rectal mucinous adenocarcinoma (synchronous, not continuous)	None	Death, 5 months	Respiratory failure	-	-	+	-
12	71	F	WLE+LAR	Rectal mucinous adenocarcinoma (synchronous, not continuous)	Yes, 10 years later	Alive, 11 years	None	-	+	+	-
13	73	M	APR	Anorectal adenocarcinoma (synchronous, not continuous)	None	Alive, 4 years	None	+	+	+	-
14	77	F	WLE	Anorectal carcinoma (continuous); HCC or cholangiocarcinoma (synchronous)	None	Death, 5 months	Liver tumor (suspected HCC or cholangiocarcinoma) with obstructive jaundice and septic shock	+	+	+	-
15	77	M	APR	Anorectal mucinous carcinoma (continuous)	None	Death, 2 years	Anorectal mucinous carcinoma with bone metastasis	+	+	+	-
16	77	M	APR	Anorectal adenocarcinoma (continuous)	None	Death, 4 years	Anorectal carcinoma with bone and lung metastases	F	+	+	-
17	73	M	APR	Anorectal adenocarcinoma (continuous)	None	Alive, 5 years	None	-	-	+	-
18	71	M	N/A	Anorectal adenocarcinoma (continuous)	Unknown	Unknown, lost follow-up	None	-	+	+	-
19	50	F	APR	Anorectal mucinous carcinoma (continuous)	None	Death, 2 years	Anorectal mucinous carcinoma with abdominal cavity, lung, and cerebellar metastases	+	+	+	-
20	88	M	N/A	Anorectal adenocarcinoma (continuous)	None	Death, 1 year	Congestive heart failure	-	+	+	-
21	81	M	APR	Anorectal adenocarcinoma (continuous)	None	Alive, 3 years	None	-	+	+	-
22	79	M	APR	Anorectal adenocarcinoma (continuous)	Unknown	Unknown, lost follow-up	None	+	-	-	-
23	64	F	WLE	Rectal adenocarcinoma (continuous)	None	Alive, 1 year	None	-	+	+	-

^aF: focally positive. PPD: perianal Paget’s disease; APR: abdominal peritoneal resection; WLE: wide local excision; LAR: low anterior resection; HCC: hepatocellular carcinoma; N/A: not applicable.