Changes in the Management of Patients with Crohn’s Disease Based on Magnetic Resonance Enterography Patterns
Table 1
Characteristics of the patients and disease stratification based on magnetic resonance enterography.
Baseline characteristic
All patients ()
Inflammatory pattern ()
Penetrating pattern ()
Fibrostenosing pattern ()
Mixed pattern ()
No abnormality ()
value
Age, median (years)
45.5 (33.7-58)
45.5 (38.2-59.3)
56 (16-)
51 (45-)
51 (30.2-58)
41 (23-55)
0.154
Disease duration (years)
7.5 (4.7-15.3)
5.0 (3.7-15)
6.0 (0-)
14.5 (12-)
9.5 (5.2-21.5)
6.0 (3-10)
0.091
Females
41 (55.4%)
7 (50.0%)
1 (33.3%)
2 (100.0%)
21 (58.3%)
10 (52.6%)
0.781
Age at diagnosis (years)
A1 (<17)
6 (8.1%)
0 (0.0%)
1 (33.3%)
0 (0.0%)
1 (2.8%)
4 (21.1%)
0.350
A2 (17–40)
42 (56.8%)
9 (64.3%)
0 (0.0%)
2 (100.0%)
23 (63.9%)
8 (42.1%)
A3 (>40)
26 (35.1%)
5 (35.7%)
2 (66.7%)
0 (0.0%)
12 (33.3%)
7 (36.8%)
Behaviour
B1 (inflammatory)
22 (29.7%)
7 (50.0%)
0 (0.0%)
0 (0.0%)
6 (16.7%)
9 (47.4%)
0.109
B2 (stricturing)
22 (29.7%)
4 (28.6%)
0 (0.0%)
2 (100.0%)
12 (33.3%)
4 (21.1%)
B3 (penetrating)
30 (40.5%)
3 (21.4%)
3 (100.0%)
0 (0.0%)
18 (50.0%)
6 (31.6%)
Location
L1 (ileal)
18 (24.3%)
4 (28.6%)
0 (0.0%)
1 (50.0%)
9 (25.0%)
4 (21.1%)
0.452
L2 (colonic)
13 (17.6%)
1 (7.1%)
1 (33.3%)
0 (0.0%)
4 (11.1%)
7 (36.8%)
L3 (ileocolonic)
43 (58.1%)
9 (64.3%)
2 (66.7%)
1 (50.0%)
23 (63.9%)
8 (42.1%)
Perianal disease
16 (21.6%)
3 (21.4%)
3 (100.0%)
0 (0.0%)
7 (19.4%)
3 (15.8%)
0.481
Proximal disease
6 (8.1%)
1 (7.1%)
0 (0.0%)
0 (0.0%)
4 (11.1%)
1 (5.3%)
0.604
Previous surgery
27 (36.5%)
4 (28.6%)
0 (0.0%)
0 (0.0%)
13 (36.1%)
10 (52.6%)
0.092
EIM
14 (18.9%)
1 (7.1%)
2 (66.7%)
1 (50.0%)
9 (25.0%)
1 (5.3%)
0.080
Smoking history
13 (17.6%)
2 (14.2%)
0 (0.0%)
0 (0.0%)
6 (16.7%)
5 (26.3%)
0.251
HBI
Activity
28 (37.8%)
6 (42.9%)
1 (33.3%)
1 (50.0%)
16 (44.4%)
4 (21.1%)
0.082
Remission
46 (62.2%)
8 (57.1%)
2 (66.7%)
1 (50.0%)
20 (55.6%)
15 (78.9%)
CRP (mg/L)
2.8 (1.4-5.5)
2.6 (1.3-3.0)
1.1 (1.0-)
4.3 (4.3-)
3.6 (2.1-6.0)
2.3 (0.5-16.3)
0.772
ESR (mm/h)
28 (16-41)
37 (20-56)
25 (17-)
41 (41-)
28 (15-40)
19 (10-35)
0.467
Haemoglobin (g/dL)
13.0 (11.5-13.7)
12.1 (9.8-13.3)
12.5 (11-)
13.0 (13.0-)
12.9 (11.5-13.8)
13.3 (12.8-13.8)
0.205
Calprotectin (μg/g)
177 (83-492)
201 (110-299)
55 (30-)
72 (72-)
299 (98-997)
100 (20-180)
0.238
Colonoscopy scores
SES-CD ()
4 (1-10)
3.5 (1-11.3)
9 (2-)
5 (4-)
6.5 (1.0-12.3)
3.5 (0-7.8)
0.297
Rutgeerts score ()
1 (0-3)
2 (0.25-3.0)
—
—
2 (0-3.0)
0 (0-2.5)
0.390
Treatment
IMM only
47 (63.5%)
10 (71.4%)
3 (100.0%)
2 (100.0%)
21 (58.3%)
11 (57.9%)
0.561
Biologics (±IMM)
27 (36.5%)
4 (28.6%)
0 (0.0%)
0 (0.0%)
15 (41.7%)
8 (42.1%)
Change in management
31 (41.9%)
6 (42.9%)
3 (100.0%)
0 (0.0%)
21 (58.3%)
1 (5.3%)
<0.001
Values are presented as the median with the interquartile range or as with the percentage; EIM: extraintestinal manifestation; HBI: Harvey and Bradshaw index; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; SES-CD: scoring endoscopic system for Crohn’s disease; IMM: immunomodulator.
