Research Article
Fibrinogen and Albumin Score Changes during Preoperative Treatment Can Predict Prognosis in Patients with Locally Advanced Rectal Cancer
Table 3
Univariate analysis for 3-year DFS and OS rate.
| Variables | | 3-year DFS | | 3-year OS | |
| Age | | | 0.690 | | 0.167 | ≤60 | 53 | 79.2% | | 83.0% | | >60 | 53 | 77.4% | | 86.8% | | Sex | | | 0.950 | | 0.647 | Female | 32 | 75% | | 84.4% | | Male | 74 | 79.7% | | 85.1% | | Distance from anal verge (cm) | | | 0.127 | | 0.569 | ≤5 | 56 | 73.2% | | 82.1% | | >5 | 50 | 84% | | 88% | | Pathologic differentiation | | | 0.008 | | 0.030 | Well and moderately | 91 | 81.3% | | 87.9% | | Poorly and mucinous | 15 | 60.0% | | 66.7% | | CEA (ng/ml) | | | ≤0.001 | | 0.001 | ≤5 | 69 | 91.3% | | 95.7% | | >5 | 37 | 54.1% | | 64.9% | | CA19-9 (ng/ml) | | | 0.013 | | 0.001 | ≤37 | 85 | 83.5% | | 90.6% | | >37 | 21 | 57.1% | | 61.9% | | Pathologic T stage | | | 0.332 | | 0.931 | T0-2 | 75 | 81.3% | | 85.3% | | T3-4 | 31 | 71.0% | | 83.9% | | Pathologic N stage | | | 0.001 | | 0.005 | N0 | 80 | 85.0% | | 88.8% | | N+ | 26 | 57.7% | | 73.1% | | LVI | | | 0.536 | | 0.566 | Negative | 90 | 78.9% | | 84.4% | | Positive | 16 | 75.0% | | 87.5% | | PNI | | | 0.980 | | 0.537 | Negative | 89 | 79.8% | | 84.3% | | Positive | 17 | 70.6% | | 88.2% | | pCR | | | 0.024 | | 0.033 | Yes | 23 | 95.7% | | 95.7% | | No | 83 | 73.5% | | 81.9% | | Downstage | | | 0.003 | | 0.022 | Yes | 63 | 87.3% | | 90.5% | | No | 43 | 65.1% | | 76.7% | | FA score | | | 0.028 | | 0.002 | FA score decreased or unchanged | 84 | 82.1% | | 89.3% | | FA score increased | 22 | 63.6% | | 68.2% | |
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CEA: carcinoembryonic antigen; CA19-9: carbohydrate antigen 19-9; LVI: lymph vascular invasion; PNI: perineural invasion; pCR: pathologic complete response; CRT: chemoradiotherapy; FA: fibrinogen and albumin.
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