Fibrinogen and Albumin Score Changes during Preoperative Treatment Can Predict Prognosis in Patients with Locally Advanced Rectal Cancer

Table 3

Univariate analysis for 3-year DFS and OS rate.

Variables		3-year DFS		3-year OS
Age			0.690		0.167
≤60	53	79.2%		83.0%
>60	53	77.4%		86.8%
Sex			0.950		0.647
Female	32	75%		84.4%
Male	74	79.7%		85.1%
Distance from anal verge (cm)			0.127		0.569
≤5	56	73.2%		82.1%
>5	50	84%		88%
Pathologic differentiation			0.008		0.030
Well and moderately	91	81.3%		87.9%
Poorly and mucinous	15	60.0%		66.7%
CEA (ng/ml)			≤0.001		0.001
≤5	69	91.3%		95.7%
>5	37	54.1%		64.9%
CA19-9 (ng/ml)			0.013		0.001
≤37	85	83.5%		90.6%
>37	21	57.1%		61.9%
Pathologic T stage			0.332		0.931
T0-2	75	81.3%		85.3%
T3-4	31	71.0%		83.9%
Pathologic N stage			0.001		0.005
N0	80	85.0%		88.8%
N+	26	57.7%		73.1%
LVI			0.536		0.566
Negative	90	78.9%		84.4%
Positive	16	75.0%		87.5%
PNI			0.980		0.537
Negative	89	79.8%		84.3%
Positive	17	70.6%		88.2%
pCR			0.024		0.033
Yes	23	95.7%		95.7%
No	83	73.5%		81.9%
Downstage			0.003		0.022
Yes	63	87.3%		90.5%
No	43	65.1%		76.7%
FA score			0.028		0.002
FA score decreased or unchanged	84	82.1%		89.3%
FA score increased	22	63.6%		68.2%

CEA: carcinoembryonic antigen; CA19-9: carbohydrate antigen 19-9; LVI: lymph vascular invasion; PNI: perineural invasion; pCR: pathologic complete response; CRT: chemoradiotherapy; FA: fibrinogen and albumin.