Research Article
Fibrinogen and Albumin Score Changes during Preoperative Treatment Can Predict Prognosis in Patients with Locally Advanced Rectal Cancer
Table 4
Multivariate analysis for 3-year DFS and OS.
| | Disease-free survival | Overall survival | HR | 95% CI | | HR | 95% CI | |
| Pathologic differentiation (well and moderately vs. poorly and mucinous) | 3.922 | 1.519-10.125 | 0.005 | 2.592 | 0.972-6.9121 | 0.057 | CEA (≤5 ng/ml vs. >5 ng/ml) | 5.741 | 2.407-13.690 | ≤0.001 | 3.832 | 1.646-8.924 | 0.002 | CA19-9 (≤37 ng/ml vs. >37 ng/ml) | 1.566 | 0.704-3.484 | 0.272 | 2.022 | 0.879-4.650 | 0.098 | Pathologic N stage (N0 vs. N+) | 2.381 | 0.817-6.935 | 0.112 | 1.989 | 0.626-6.316 | 0.243 | pCR (yes vs. no) | 2.909 | 0.624-13.561 | 0.174 | 3.300 | 0.720-15.215 | 0.124 | Downstage (yes vs. no) | 0.828 | 0.255-2.690 | 0.754 | 0.743 | 0.217-2.541 | 0.636 | FA score changes (decreased or unchanged vs. increased) | 2.433 | 1.102-5.375 | 0.028 | 3.325 | 1.468-7.532 | 0.002 |
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CEA: carcinoembryonic antigen; CA19-9: carbohydrate antigen 19-9; pCR: pathologic complete response; FA: fibrinogen and albumin; HR: hazard ratio; CI: confidential interval.
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