Fibrinogen and Albumin Score Changes during Preoperative Treatment Can Predict Prognosis in Patients with Locally Advanced Rectal Cancer

Table 4

Multivariate analysis for 3-year DFS and OS.

	Disease-free survival			Overall survival
	HR	95% CI		HR	95% CI
Pathologic differentiation (well and moderately vs. poorly and mucinous)	3.922	1.519-10.125	0.005	2.592	0.972-6.9121	0.057
CEA (≤5 ng/ml vs. >5 ng/ml)	5.741	2.407-13.690	≤0.001	3.832	1.646-8.924	0.002
CA19-9 (≤37 ng/ml vs. >37 ng/ml)	1.566	0.704-3.484	0.272	2.022	0.879-4.650	0.098
Pathologic N stage (N0 vs. N+)	2.381	0.817-6.935	0.112	1.989	0.626-6.316	0.243
pCR (yes vs. no)	2.909	0.624-13.561	0.174	3.300	0.720-15.215	0.124
Downstage (yes vs. no)	0.828	0.255-2.690	0.754	0.743	0.217-2.541	0.636
FA score changes (decreased or unchanged vs. increased)	2.433	1.102-5.375	0.028	3.325	1.468-7.532	0.002

CEA: carcinoembryonic antigen; CA19-9: carbohydrate antigen 19-9; pCR: pathologic complete response; FA: fibrinogen and albumin; HR: hazard ratio; CI: confidential interval.