Expression Analysis of Fibronectin Type III Domain-Containing (FNDC) Genes in Inflammatory Bowel Disease and Colorectal Cancer

Table 4

Summary of IBD and CRC analysis and main proposed functions of FNDCs and GPR116.

Gene	Regulation in IBD	Regulation in CRC	Proposed function
FNDC1	Upregulated	Unchanged	Angiogenesis, apoptosis
FNDC3A	Unchanged	Trends upregulated	Organogenesis
FNDC3B	Unchanged	Unchanged	Cancer pathway activator
FNDC4	Upregulated	Unchanged/downregulated	Anti-inflammatory
FNDC5	Unchanged	Unchanged	Energy metabolism
GPR116	Unchanged	Unchanged/upregulated	FNDC4 receptor candidate

depending on CRC subtypes.