Association of Ulcerative Colitis with FOXP3 Gene Polymorphisms and Its Colonic Expression in Chinese Patients
Table 2
Allelic and genotypic distribution of FOXP3 polymorphisms in patients with ulcerative colitis (UC) and healthy controls (HC) [frequency (%)].
FOXP3
Female HC ()
Female UC ()
Male HC ()
Male UC ()
rs3761548
CC
172 (63.7)
126 (54.3)
CA
77 (28.5)
73 (31.5)
AA
21 (7.8)
33 (14.2)
CA + AA
98 (36.3)
106 (45.7)a
C
421 (78.0)
325 (70.0)
204 (80.0)
172 (71.7)
A
119 (22.0)
139 (30.0)b
51 (20.0)
68 (28.3)g
rs2232365
AA
111 (41.1)
72 (31.0)
AG
110 (40.7)
105 (45.3)
GG
49 (18.2)
55 (23.7)
AG + GG
159 (58.9)
160 (69.0)c
A
332 (61.5)
249 (53.7)
174 (68.2)
138 (57.5)
G
208 (38.5)
215 (46.3)d
81 (31.8)
102 (42.5)h
rs2294021
CC
80 (29.6)
50 (21.5)
CT
108 (40.0)
93 (40.1)
TT
82 (30.4)
89 (38.4)
CT + TT
190 (70.4)
182 (78.5) e
C
268 (49.63)
193 (41.6)
113 (44.3)
83 (34.6)
T
272 (50.37)
271 (58.4)f
142 (55.7)
157 (65.4)i
rs3761547
CC
27 (10.00)
16 (6.9)
CA
63 (23.33)
58 (25.0)
AA
180 (66.67)
158 (68.1)
CA + AA
243 (90.00)
216 (93.1)
C
117 (21.67)
90 (19.4)
52 (20.4)
50 (20.8)
A
423 (78.33)
374 (80.6)
203 (79.6)
190 (79.2)
All listed and OR values were calculated for each SNP analyzed using logistic regression after adjusted for age, gender, and smoking. ,,95% CI 1.032-2.112. ,,95% CI 1.139-2.011. ,,95% CI 1.073-2.244. ,,95% CI 1.072-1.773. ,,95% CI 1.020-2.304. ,,95% CI 1.077-1.777. ,,95% CI 1.043-2.397. ,,95% CI 1.100-2.293. ,,95% CI 1.047-2.164.
