Association of Ulcerative Colitis with FOXP3 Gene Polymorphisms and Its Colonic Expression in Chinese Patients

Table 4

Association of FOXP3 polymorphisms with the clinical features in male patients with ulcerative colitis (UC) [frequency (%)].

FOXP3	Severity of UC		Extent of UC
	Mild and moderate ()	Severe ()	Distal colitis ()	Extensive colitis ()
rs3761548
C	129 (79.6)	43 (55.1)	100 (69.4)	72 (75.0)
A	33 (20.4)	35 (44.9)^a	44 (30.6)	24 (25.0)
rs2232365
A	103 (63.6)	35 (44.9)	85 (59.0)	53 (55.2)
G	59 (36.4)	43 (55.1)^b	59 (41.0)	43 (44.8)
rs2294021
C	63 (38.9)	20 (25.6)	50 (34.7)	33 (34.4)
T	99 (61.1)	58 (74.4)^c	94 (65.3)	63 (65.6)
rs3761547
C	35 (21.6)	15 (19.2)	32 (22.2)	18 (18.7)
A	127 (78.4)	63 (80.8)	112 (77.8)	78 (81.3)

All listed ORs, 95% CIs, and value were calculated for each SNP analyzed using logistic regression after adjusted for age, gender, and smoking. ,,95% CI 1.768-5.726. ,,95% CI 1.239-3.714. ,,95% CI 1.014-3.357.