Association of Ulcerative Colitis with FOXP3 Gene Polymorphisms and Its Colonic Expression in Chinese Patients

Table 5

Linear regression analysis for the related factors influencing the mRNA expression of Foxp3 in UC patients.

Covariants	Unstandardized coefficients		Standardized coefficients			95% CI for
		S.E.
Age^a	0.000	0.001	-0.009	-0.061	0.952	-0.003-0.002
Gender^b	-0.003	0.001	-0.341	-2.654	0.013	-0.005--0.001
rs3761548^c	-0.001	0.002	-0.057	-0.282	0.780	-0.004-0.003
rs2232365^c	-0.001	0.001	-0.172	-1.067	0.295	-0.004-0.001
rs2294021^c	-0.004	0.001	-0.503	-3.581	0.001	-0.007--0.002
rs3761547^c	0.002	0.001	0.191	1.551	0.132	-0.001-0.004
Severity of UC^d	0.003	0.001	0.361	2.640	0.013	0.001-0.006
Location of UC^e	0.000	0.001	0.029	0.218	0.829	-0.002-0.003

^aWith reference to age < 40 years older. ^bWith reference to female. ^cWith reference to patients without any variant allele of FOXP3 (rs3761548, rs2232365, rs2294021, and rs3761547), respectively. ^dWith reference to mild and moderate UC. ^eWith reference to distal colitis. CI: confidence interval.