A Novel Severity Score Index for Febrile Neutropenic Patients with Colorectal Diseases

Table 2

(a) Five main predictors of in-hospital mortality according to the medical literature, common biological plausibility criteria, clinical experience of the authors, calculations of effect measures, and statistical analysis of the sample data. (b) Three groups according to points assigned on the proposed severity scale. Group I (5-8 points), group II (9-12 points), and group III (13-16 points).

(a) Variable		Score
Underlying disease	MM, ES, EM	1
	NHL (moderate and low grade), HL, CLL	2
	AA, MDS, accelerated phase CML	3
	AML, ALL, high-grade NHL, blastic phase CML	4
Neutropenia classification (number of neutrophils)	Mild: between 1000 and 501 cells/mm^3	1
	Moderate: between 500 and 100 cells/mm^3	2
	Severe: ≤100 cells/mm^3	3
Duration of neutropenia	≤7 days	1
	8-14 days	2
	≥15 days	3
Current therapeutic modality	Autologous HSCT/other treatments	1
	Combination drug chemotherapy	2
	Allogenic HSCT	3
Colorectal disorder	Nonseptic anorectal focus	1
	Septic anorectal focus	2
	Abdominal focus	3
(b) Group	Score
I	5-8
II	9-12
III	13-16

Based on this process, a severity score scale was created to estimate the risk of in-hospital death of febrile neutropenic hematologic patients with a diagnosed abdominal or anorectal focus.