Risk of Colorectal Cancer in Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis

Table 1

Population and study characteristics.

Author	Sample size (UC)	Study period	Mean age at diagnosis (UC)	Country	Sample size (CRC)	Mean age at diagnosis (CRC)	Gender		Disease extent			Time of duration (year)
							Men	Women	Extensive	Left-sided	Proctitis
Hata et al. [7]	217	1979-2001	31.4	Japan	5	46.6	0	0	4	1	0	15.2
Kim et al. [8]	7061	1970-2005	37.9	Korea	26	49.6	8	18	0	0	0	12.7
Gong et al. [9]	3922	1998-2009	40	China	34	57.5	14	20	10	12	12	12.8
Matsuoka et al. [10]	1274	1984-2010	30	Japan	83	52	43	40	66	17	10	22
Zhang et al. [11]	624	2000-2012	39	China	4	54.5	2	2	4	0	0	15.5
Lee et al. [12]	2798	1989-2013	33	Korea	18	48	7	11	16	2	0	15
Choi et al. [13]	522	2003-2013	0	Korea	12	0	0	0	0	0	0	0
Shi et al. [14]	1225	1981-2013	41	China	15	0	0	0	0	0	0	0
Yoshino et al. [15]	2137	2003-2013	0	Japan	43	53	28	15	34	8	1	13
Wang et al. [16]	2663	1998-2013	43.1	China	18	0	0	0	0	0	0	19.27
Jung et al. [17]	9785	2011-2014	0	Korea	31	0	20	11	0	0	0	0
Kishikawa et al. [18]	289	1979-2014	33	Japan	9	49	5	4	28	5	0	16
Bopanna et al. [19]	1012	2004-2015	32.1	India	20	53.25	14	6	16	4	0	18.7
Selinger et al. [20]	504	1977-1992	0	Australia	24	0	0	0	12	8	4	0
Gupta et al. [21]	418	1996-1997	26.8	USA	1	0	0	0	0	0	0	0
Jess et al. [22]	378	1940-2001	34	USA	6	50.67	4	2	4	2	0	13.67
Bitton et al. [23]	15346	1999-2008	0	Canada	53	0	37	16	0	0	0	0
Hou et al. [24]	20949	1998-2009	0	USA	168	67	97	71	0	0	0	3.6
Ananthakrishnan et al. [25]	5569	1998-2010	0	USA	126	0	0	0	0	0	0	0
Navaneethan et al. [26]	997	1998-2011	0	USA	2	0	0	0	0	0	0	0
Yadav et al. [5]	462	1940-2011	35	USA	13	66	6	7	0	0	0	31
Ananthakrishnan et al. [27]	3546	2010-2013	0	USA	83	0	0	0	0	0	0	0
Sonnenberg and Genta [28]	37043	2008-2014	49.6	USA	54	0	0	0	0	0	0	0
Hou et al. [29]	881	1999-2014	0	USA	21	0	0	0	0	0	0	0
Bettner et al. [30]	75	1990-2015	29	USA	1	59	0	0	0	0	0	11.1
Gyde et al. [4]	823	1944-1976	33.66	UK/Sweden	35	56.69	13	22	28	7	0	23.03
Moody et al. [31]	175	1972-1981	58.4	UK	10	67	6	4	7	3	0	9.6
Ekbom et al. [32]	3117	1922-1983	0	Sweden	91	0	52	39	35	17	9	0
Lennard-Jones et al. [33]	401	1966-1987	29.73	UK	22	50.05	13	9	0	0	0	20.31
Löfberg et al. [34]	72	1973-1988	0	Sweden	1	42.25	0	0	0	0	0	0
Stewtnius et al. [35]	471	1958-1990	38.3	Sweden	9	49.88	3	6	7	1	1	12.22
Biasco et al. [36]	65	1980-1992	32.9	Italy	4	59.5	0	0	0	0	0	13
Wandall et al. [37]	801	1973-1993	41	Denmark	6	57.33	4	2	4	1	1	10.83
Palli et al. [38]	689	1978-1996	0	Italy	4	0	0	0	0	0	0	0
Winther et al. [39]	1160	1962-1997	0	Denmark	8	0	6	2	0	0	0	0
Viscido et al. [40]	2006	1964-1997	38.5	Italy	28	0	0	0	0	0	0	0
Goldacre et al. [41]	6990	1963-1999	0	UK	103	0	0	0	0	0	0	0
Lindberg et al. [42]	90	1977-2002	0	Sweden	8	0	0	0	0	0	0	0
Jess et al. [43]	1437	1978-2002	0	Denmark	15	0	0	0	0	0	0	0
Hemminki et al. [44]	27606	1964-2004	0	Germany/Sweden	482	0	0	0	0	0	0	0
Katsanos et al. [45]	182	1983-2004	51.2	Greece	3	0	2	1	0	0	0	0
Katsanos et al. [46]	776	1991-2004	0	Netherlands	7	61.3	0	0	0	0	0	5.4
Jess et al. [47]	1575	1962-2005	0	Denmark	14	0	8	6	0	0	0	0
Stolwijk et al. [48]	293	1980-2005	33.8	Netherlands	23	49.2	14	9	22	1	0	10.2
Lakatos et al. [49]	723	2002-2005	36	Hungary	13	51	0	0	8	5	0	19
Cheddani et al. [50]	474	1998-2006	69	France	8	75	0	0	0	0	0	7.4
Manninen et al. [51]	1254	1986-2007	34	Finland	16	47.69	14	2	10	6	0	16.1875
Jess et al. [52]	32911	1979-2008	44.9	Denmark	268	64	132	136	0	0	0	19.1
Gordillo et al. [53]	403	2006-2009	42.91	Spain	3	58.9	3	0	2	1	0	12.5
Kappelman et al. [54]	35152	1978-2010	46.5	Denmark	437	0	0	0	0	0	0	7.8
Choi et al. [55]	1375	2003-2012	30	UK	88	55.5	54	34	0	0	0	25.5
Choi et al. [56]	987	2003-2012	30	UK	14	0	0	0	0	0	0	0
Hovde et al. [57]	519	1990-2013	0	Norway	14	0	10	4	0	0	0	0
Van den Heuvel et al. [58]	1644	1991-2013	45	Netherlands	12	62.75	6	6	4	7	1	3.42
Nowacki et al. [59]	434	2013-2013	45.7	Germany	10	54.7	5	5	6	4	0	12
Rutegård et al. [60]	323	1977-2014	0	Sweden	10	0	0	0	0	0	0	0
Biancone et al. [61]	22666	2012-2014	0	Italy	24	64	0	0	0	0	0	12
Kekilli et al. [62]	275	1994-2008	35.9	Turkey	3	0	0	0	0	0	0	0