The Effect of Splenectomy on the Reversal of Cirrhosis: a Prospective Study
Table 3
Multivariate linear regression of serum markers with GEE models.
Parameters
HA (μg/l)
LN (μg/l)
PIIINP (μg/l)
C-IV (μg/l)
1 (95% CI)
(95% CI)
(95% CI)
(95% CI)
Sex
Male
ref.
—
ref.
—
ref.
—
ref.
—
Female
−14.75 (−89.27-59.78)
0.698
12.73 (−48.92-74.38)
0.686
−0.12 (−2.32-2.08)
0.915
−6.88 (−24.92-11.15)
0.455
Age, year
4.07 (0.31-7.84)
0.034
1.50 (−0.93-3.92)
0.227
0.11 (0.00-0.21)
0.045
1.05 (0.22-1.88)
0.013
Child-Pugh score
49.69 (-20.02-119.39)
0.162
34.09 (−26.09-94.26)
0.267
2.26 (0.58-3.95)
0.008
15.07 (5.17-24.97)
0.003
Time
Preoperation
ref.
—
ref.
—
ref.
—
ref.
—
1 week
52.80 (8.43-97.17)
0.020
0.81 (−12.76-14.38)
0.907
−1.73 (−4.37-0.92)
0.201
−21.19 (−48.56-6.19)
0.129
1 month
123.87 (12.83-234.90)
0.029
−15.00 (−29.98--0.03)
0.050
−5.52 (−7.86--3.18)
<0.001
−48.54 (−70.35--26.73)
<0.001
3 months
10.17 (−22.15-42.50)
0.537
−6.89 (−23.54-9.76)
0.417
−5.60 (−8.01--3.19)
<0.001
−54.78 (−79.15--30.42)
<0.001
6 months
23.12 (−49.08-95.32)
0.530
−16.24 (−34.62-2.13)
0.083
−6.38 (−9.62--3.13)
<0.001
−63.31 (−89.55--37.08)
<0.001
12 months
41.75 (−112.45-195.95)
0.596
−1.37 (−23.61-20.86)
0.904
−7.21 (−10.17--4.25)
<0.001
−66.07 (−91.38--40.75)
<0.001
1Regression coefficient β. Abbreviations: CI: confidence interval; HA: hyaluronan; LN: laminin; PIIINP: amino-terminal propeptide of type III procollagen; C-IV: type IV collagen.
