Preoperative Serum IL6, IL8, and TNF-α May Predict the Recurrence of Hepatocellular Cancer

Table 2

Univariate and multivariate analyses of risk factors for recurrence-free survival.

Factor	Univariable analysis		Multivariable analysis
	HR (95% CI)	value	HR (95% CI)	value
Age (years)
≥60	0.99 (0.61-1.60)	0.964
<60
Gender
Male	0.78 (0.44-1.38)	0.398
Female
HBV
Yes	0.97 (0.64-1.49)	0.902
No
Cirrhosis
Yes	0.91 (0.56-1.46)	0.681
No
Differentiation
Poor	0.68 (0.44-1.04)	0.078
Well
AFP (μg/l)
>636	1.51 (0.97-2.34)	0.069
≤636
Maximum tumor size (cm)
≥5	2.37 (1.48-3.81)	<0.001	1.72 (1.03-2.89)	0.039
<5
MVI
Yes	2.47 (1.59-3.83)	<0.001	1.86 (1.15-2.99)	0.011
No
Preoperative serum IL6 (pg/ml)
>8.45	4.69 (2.82-7.81)	<0.001	4.42 (2.58-7.58)	<0.001
≤8.45
Preoperative serum IL8 (pg/ml)
>68	2.80 (1.84-4.28)	<0.001	1.73 (1.12-2.68)	0.013
≤68
Preoperative serum TNFα (pg/ml)
>14.9	9.15 (3.70-22.60)	<0.001	5.48 (2.18-13.81)	<0.001
≤14.9

Abbreviations: AFP: α-fetoprotein; HR: hazard rate; CI: confidence interval; MVI: microvascular invasion.