Evaluation of the Eighth Edition of the American Joint Committee on Cancer TNM Staging System for Gastric Cancer: An Analysis of 7371 Patients in the SEER Database

Table 2

Univariate analysis and 3-step multivariate analysis of prognostic factors for gastric cancer patients.

	Univariate analysis			Multivariate analysis 1st			Multivariate analysis 2nd			Multivariate analysis 3rd
	HR	95% CI	value	HR	95% CI	value	HR	95% CI	value	HR	95% CI	value
Age	1.234	1.151-1.322	<0.001	1.472	1.372-1.579	<0.001	1.473	1.374-1.580	<0.001	1.453	1.355-1.559	<0.001
Gender	1.038	0.967-1.115	0.297
Race	0.866	0.831-0.903	<0.001	0.880	0.844-0.918	<0.001	0.880	0.844-0.918	<0.001	0.876	0.840-0.913	<0.001
Tumor site	1.018	0.999-1.037	0.059
Tumor size	1.373	1.310-1.440	<0.001	1.139	1.080-1.200	<0.001	1.135	1.077-1.197	<0.001	1.120	1.062-1.182	<0.001
Grade	1.220	1.167-1.275	<0.001	1.113	1.056-1.174	<0.001	1.110	1.052-1.170	<0.001	1.099	1.042-1.159	0.001
TNM stage (AJCC 7th)	1.511	1.482-1.541	<0.001	1.504	1.475-1.534	<0.001	1.081	1.002-1.166	0.044
TNM stage (AJCC 8th)	1.530	1.500-1.560	<0.001				1.413	1.310-1.524	<0.001
Revised TNM system	1.501	1.482-1.511	<0.001							1.333	1.249-1.410	<0.001