The Value of Pepsinogen in GC Screening: A Systematic Review and Meta-Analysis

Table 1

Basic characteristics of the study.

Reference	Location	Sample size	Age	Gold standard	TP	FP	FN	TN	Critical value	Inspection method
Li et al. [8]	Hebei, China	720	—	Pathology	50	136	73	461	PGR ≤ 6.0	TRFIA
Zhang et al. [9]	Hebei, China	720	—	Pathology	18	38	105	559	PGI < 60 μg/L; PGR ≤ 6.0	TRFIA
Kang et al. [10]	Korea	1006	57.6 ± 13.2	Pathology	98	63	67	102	PGR ≤ 3.0	LEI
Yu et al. [11]	Beijing, China	2668	—	Pathology	60	279	88	2241	PGI ≤ 0.7 μg/L; PGR ≤ 3.0	ABA
Mizuno et al. [12]	Japan	12,120	15~84	Barium meal	7	486	12	116; 15	PGI ≤ 30 ng/mL; PGR ≤ 2.0	CT
Miki et al. [13]	Japan	101,892	—	Pathology	115	902; 1	10	464; 3	PGI ≤ 70 ng/mL; PGR ≤ 3.0	RIA
Zhang et al. [14]	Gansu, China	918	>50	Pathology	3	197	4	714	PGI ≤ 70 μg/L; PGR ≤ 3.0	ABA
Zhang et al. [15]	Gansu, China	1502	—	Pathology	6	576	3	917	PGI ≤ 70 ng/mL; PGR ≤ 7.0	ELISA
Yuan [16]	Liaoning, China	21,338	10~87	Pathology	69	656; 0	39	146; 70	PGR ≤ 7.0	ELISA
Wei et al. [17]	Hebei, China	753	>35	Pathology	3	197	4	549	PGI ≤ 75 μg/L; PGR ≤ 3.5	LEI
Xu et al. [18]	Jiangsu, China	1028	22~91	Pathology	43	146	15	824	PGI ≤ 70 ng/mL; PGR ≤ 3.0	LEI
Lomba-Viana et al. [19]	Portugal	13,118	40~79	Pathology	6	268	3	237	PGI ≤ 70 ng/mL; PGR ≤ 3.0	ELISA
Nakajima [20]	Japan	1000	—	Barium meal	4	196	1	799	PGI ≤ 70 ng/mL; PGR ≤ 3.0	RIA
Zhao et al. [21]	Shanxi, China	725	—	Pathology	5	180	13	527	PGI ≤ 70 μg/L; PGR ≤ 3.0	ELISA
Yuan [22]	Shandong, China	160	65.2 ± 4.8	Pathology	34	26	26	74	PGI ≤ 70 ng/mL; PGR ≤ 7.0	ELISA
Zhang et al. [23]	Beijing, China	518	13~86	Pathology	102	32	23	151	PGI ≤ 62.5 μg/L; PGR ≤ 3.1	CMI
Shikata et al. [24]	Japan	2446	—	Barium meal	49	731	20	164; 6	PGI ≤ 59 ng/mL; PGR ≤ 3.9	RIA
Juan Cai et al. [25] 2017	Xinjiang, China	464	53.3 ± 13.8	Pathology	45	7	61	153	PGI ≤ 72.78 ng/m L; PGR ≤ 4.15	ELISA
Castro et al. [26] 2017	Portugal	5913	40~74	Pathology	15	210	11	567; 7	PGI ≤ 70 ng/mL; PGR ≤ 3.0	ELISA